机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[2]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School ofTraditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[3]Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou510515, Guangdong, China[4]Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong, China
Acute hepatic damage is a severe condition characterized by inflammation and oxidative stress, which is a serious threat to people's life and health. But there are few effective treatments for acute liver injury. Therefore, safe and effective therapeutic approaches for preventing acute liver damage are urgently needed. Lupeol is a natural compound, which has significant antioxidant and anti-inflammatory properties in liver disease. However, the protective mechanism of lupeol against acute liver injury remains unclear. Here, zebrafish and mutant mice were utilized to investigate the protective effects of lupeol against lipopolysaccharide (LPS)/ D-galactosamine(D-GalN) -induced liver injury and the underlying mechanisms. We found that pretreatment with lupeol attenuated the LPS/D-GalN-induced liver injury by decreasing the infiltration of inflammatory cells and reducing pro-inflammatory cytokines. We also demonstrated that lupeol could protect injured liver from oxidative stress by downregulating the expression of TGFβ1 and upregulating Nrf2. Notably, our experimental results provided the support that lupeol effectively protected against LPS/D-GalN-induced acute liver injury via suppression of inflammation response and oxidative stress, which were largely dependent on the upregulation of the Nrf2 pathway via downregulating TGFβ1.
基金：
the National Natural Science
Foundation of China (81774170, 82074131, 81603501
and 81673774), the Natural Science Foundation of
Guangdong Province (2018B030306012), the Scientific
Research Initiative Program of Southern Medical
University (CX2017N001), and Scientific research project
in hygienism of Shenzhen Guangming District Science
and technology innovation Bureau(2020R01126).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区医学
小类|1 区老年医学3 区细胞生物学
最新[2025]版：
无
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[2]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School ofTraditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[3]Guangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou510515, Guangdong, China
推荐引用方式(GB/T 7714)：
Huang Sha,Mo Chan,Zeng Ting,et al.Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.[J].AGING-US.2021,13(5):6592-6605.doi:10.18632/aging.202409.
APA：
Huang Sha,Mo Chan,Zeng Ting,Lai Yuqi,Zhou Chuying...&Lv Zhiping.(2021).Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway..AGING-US,13,(5)
MLA：
Huang Sha,et al."Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway.".AGING-US 13..5(2021):6592-6605
医学