机构：[1]Guangdong Provincial Key Laboratory of Microbial Safety and Health and State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China[2]Guangdong Yuewei Edible Fungi Technology Co., Guangzhou, China[3]School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China[4]Affiliated Hospital of Guangdong Medical University, Zhanjiang, China[5]Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Poria coco F.A.Wolf (Polyporaceae) dispels dampness and promotes diuresis implying hypouricaemic action.
To examine hypouricaemic action of Poria coco.
Ethanol extract (PCE) was prepared by extracting the sclerotium of P. cocos with ethanol, and the water extract (PCW) was produced by bathing the remains with water. PCE and PCW (50, 100 and 200 mg/kg, respectively) were orally administered to hyperuricemic Kunming mice (n = 8) to examine its hypouricaemic effect. Also, molecular docking was performed.
P. cocos showed excellent hypouricaemic action, decreasing the serum uric acid of hyperuricaemia (HUA) control (526 ± 112 μmol/L) to 178 ± 53, 153 ± 57 and 151 ± 62 μmol/L (p < 0.01) by PCE and 69 ± 23, 63 ± 15 and 62 ± 20 μmol/L (p < 0.01) by PCW, respectively. According to SCrs, BUNs and H&E staining, PCE and PCW partially attenuated renal dysfunction caused by HUA. They presented no negative effects on ALT, AST and ALP activities. They elevated ABCG2 (ATP-binding cassette super-family G member 2) mRNA and protein expression in comparison to HUA control. In molecular docking, compound 267, 277, 13824, 15730 and 5759 were predicted as the top bioactives of P. cocos against HUA, which even presented better scores than the positive compound, oestrone 3-sulfate.
This paper demonstrated the hypouricaemic and nephroprotective effects of P. cocos in hyperuricemic mice by up-regulating ABCG2. These results may be useful for the development of a hypouricaemic agent.
基金：
National Natural Science Foundation of
China (31901696, 81701086, 81803393), Science and Technology
Program of Guangzhou (202002030225), Special Projects for
Guiding Young Scientists in GDAS (2019GDASYL-0105005), Key
Realm R&D Program of Guangdong Province (2018B020206001,
2018B020205001), Guangdong Province Science and Technology
Project (No. 2017B020201007) and Guangdong Province Sail Plan
(2017YT05S115).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区医学实验技术3 区药学3 区植物科学
最新[2025]版：
大类|3 区医学
小类|2 区医学实验技术2 区药学2 区植物科学
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of Microbial Safety and Health and State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China[2]Guangdong Yuewei Edible Fungi Technology Co., Guangzhou, China[3]School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China[4]Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Microbial Safety and Health and State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China[2]Guangdong Yuewei Edible Fungi Technology Co., Guangzhou, China[*1]Guangdong Provincial Key Laboratory of Microbial Safety and Health and State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Xianlie Road 100, Yuexiu District, Guangzhou 510070, China
推荐引用方式(GB/T 7714)：
Liang Danling,Yong Tianqiao,Diao Xue,et al.Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2.[J].Pharmaceutical biology.2021,59(1):275-286.doi:10.1080/13880209.2021.1885450.
APA：
Liang Danling,Yong Tianqiao,Diao Xue,Chen Shaodan,Chen Diling...&Hu Huiping.(2021).Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2..Pharmaceutical biology,59,(1)
MLA：
Liang Danling,et al."Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2.".Pharmaceutical biology 59..1(2021):275-286
