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A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Han-Bin Chen[a,b,c] * ; Chao-Dan Luo[d,e] * ; Gao-Xiang Ai[e] ; Yong-Fu Wang[j] ; Cai-Lan Li [k] ; Li-Hua Tan[e] ; Simon Ming-Yuen Lee[b] ; Alex Kwok-Kuen Cheung[c] ; Zi-Ren Su[e] ; Xiao-Li Wu[f] ; Jian-Hui Xie[g,h,i] ; Hui-Fang Zeng[a] ;
机构： [a]The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China [b]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China [c]Muscle Physiology Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China [d]Guangxi Institute of Subtropical Agricultural Products Processing, Guangxi Subtropical Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, 530001, People’s Republic of China [e]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China [f]School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, People’s Republic of China [g]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China [h]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China [i]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, 510120, People’s Republic of China [j]First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China [k]Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, People’s Republic of China
出处：
DOI： 10.1016/j.jpba.2021.114032
ISSN：

关键词： Berberine Hemoglobin Interaction Metabolite Pharmacokinetics

摘要：
Berberine (BBR), isolated from Coptis chinensis, is one type of isoquinoline alkaloids. BBR exerts numerous of bioactivities but the plasma concentration is really low. In our previous study, a new oxymetabolite (OBB) has been discovered and showed superior anti-inflammatory effect comparing with BBR. The aim of this study is to investigate the interaction, metabolite and pharmacokinetics of BBR with hemoglobin. Sprague-Dawley rats were used to carry out the interaction, metabolite and pharmacokinetics of BBR and OBB in vivo. Fluorescence spectra were used to analyse the interaction in vitro. Results showed that OBB could be generated after intravenous injection or incubating with BBR in vitro and in vivo; Both BBR and OBB exerted much stronger binding interaction with hemoglobin than plasma and affect the conformation of bovine hemoglobin and change the fluorescence spectral properties; BBR and OBB were mainly presented and transported in the proteins-bound form. These results provide a new insight to understand the dynamic equilibrium of BBR and OBB within body from the perspective of new metabolic pathways. © 2021 Elsevier B.V.

基金：
This work was supported by grants from National Natural Science Foundation of China (Nos. 82074082 & 82003771 ), National Natural Science Foundation of Guangdong, China ( 2019A1515010819 ), Provincial-level Major Scientific Research Projects in Ordinary Universities of Guangdong Province, China ( 2017KZDXM017 ), Key Program for Subject Research of Guangzhou University of Chinese Medicine ( XK2018016 & XK2019002 ), Characteristic Cultivation Program for Subject Research of Guangzhou University of Chinese Medicine ( XKP2019007 ), Special Project on the Integration of Industry, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine ( 2017B030314096 ), Young Innovative Talents Program, Educational Commission of Guangdong Province, China ( 2019KQNCX024 ), and Guizhou Science and Technology Foundation of China (No. QKHPTRC[2018]5772-021 ).

基金编号： Nos. 82074082 & 82003771

语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 分析化学 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 分析化学 3 区 药学
JCR分区：
出版当年[2019]版：
Q2 PHARMACOLOGY & PHARMACY Q2 CHEMISTRY, ANALYTICAL
最新[2023]版：
Q2 CHEMISTRY, ANALYTICAL Q2 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China [b]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China [c]Muscle Physiology Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构： [g]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China [h]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China [i]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, 510120, People’s Republic of China
推荐引用方式(GB/T 7714)：
Han-Bin Chen,Chao-Dan Luo,Gao-Xiang Ai,et al.A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite[J].JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2021,199:doi:10.1016/j.jpba.2021.114032.
APA：
Han-Bin Chen,Chao-Dan Luo,Gao-Xiang Ai,Yong-Fu Wang,Cai-Lan Li...&Hui-Fang Zeng.(2021).A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,199,
MLA：
Han-Bin Chen,et al."A comparative investigation of the interaction and pharmacokinetics of hemoglobin with berberine and its oxymetabolite".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 199.(2021)

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