机构：[1]School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[2]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[3]Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China[4]Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China深圳市中医院深圳医学信息中心
Apigenin (API), a natural plant flavone, is abundantly found in common fruits and vegetables. As a bioactive flavonoid, API exhibits several activities including antiproliferation and anti-inflammation. A recent study showed that API could retard osteoporosis progress, indicating its role in the skeletal system. However, the detailed function and mechanism remain obscure. In the present study, API was found to promote osteogenic differentiation of mesenchymal stem cells (MSCs). And further investigation showed that API could enhance the expression of the critical transcription factor β-catenin and several downstream target genes of Wnt signaling, thus activated Wnt/β-catenin signaling. Using a rat femoral fracture model, API was found to improve new bone formation and accelerate fracture healing in vivo. In conclusion, our data demonstrated that API could promote osteogenesis in vitro and facilitate the fracture healing in vivo via activating Wnt/β-catenin signaling, indicating that API may be a promising therapeutic candidate for bone fracture repair.NEW & NOTEWORTHY1) API promoted osteogenic differentiation of human MSCs in vitro; 2) API facilitated bone formation and accelerated fracture healing in vivo; 3) API stimulated Wnt/β-catenin signaling during osteogenesis of human MSCs.
基金：
National Natural Science
Foundation of China (81773066 to W-m. Fu, 81772404 to J-f.
Zhang).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区医学
小类|2 区生理学3 区内分泌学与代谢
最新[2025]版：
大类|2 区医学
小类|2 区生理学3 区内分泌学与代谢
第一作者：
第一作者机构：[1]School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[2]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China
通讯作者：
通讯机构：[1]School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[2]Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China[3]Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China[4]Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China
推荐引用方式(GB/T 7714)：
Pan Fei-Fei,Shao Jiang,Shi Chuan-Jian,et al.Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling.[J].American journal of physiology. Endocrinology and metabolism.2021,320(4):E760-E771.doi:10.1152/ajpendo.00543.2019.
APA：
Pan Fei-Fei,Shao Jiang,Shi Chuan-Jian,Li Zhi-Peng,Fu Wei-Ming&Zhang Jin-Fang.(2021).Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling..American journal of physiology. Endocrinology and metabolism,320,(4)
MLA：
Pan Fei-Fei,et al."Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling.".American journal of physiology. Endocrinology and metabolism 320..4(2021):E760-E771
