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β-Asarone Ameliorates β-Amyloid-Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

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收录情况： ◇ SCIE

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机构： [1]The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China, [2]Department of Clinical Education Management, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China, [3]College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China, [4]Department of Neurology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

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关键词： β -asarone Alzheimer’ s disease oxidative stress P13K Akt Nrf2 signaling pathway Aβ 1-42

摘要：

Accumulation of beta-amyloid (A beta) causes oxidative stress, which is the major pathological mechanism in Alzheimer's disease (AD). beta-asarone could reduce A beta-induced oxidative stress and neuronal damage, but the molecular mechanism remains elusive. In this study, we used an A beta-stimulated PC12 cell model to explore the neuroprotective effects and potential mechanisms of beta-asarone. The results showed that beta-asarone could improve cell viability and weaken cell damage and apoptosis. beta-asarone could also decrease the level of ROS and MDA; increase the level of SOD, CAT, and GSH-PX; and ameliorate the mitochondrial membrane potential. Furthermore, beta-asarone could promote the expression of Nrf2 and HO-1 by upregulating the level of PI3K/Akt phosphorylation. In conclusion, beta-asarone could exert neuroprotective effects by modulating the P13K/Akt/Nrf2 signaling pathway. beta-asarone might be a promising therapy for AD.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

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出版当年[2019]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 5 最新五年平均 4.225 出版当年[2019版] 4.604 出版当年五年平均 3.845 出版前一年[2018版] 5.811 出版后一年[2020版]

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第一作者机构： [1]The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China,

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