机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院肾内科大德路总院肾内科广东省中医院[2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China[3]Department of Nephrology, Weihai Hospital of Traditional Chinese Medicine, Weihai, China[4]Guangdong-Hong Kong Joint Laboratory for Immunity and Genetics of Chronic Kidney Disease, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, China[5]Guangdong-Hong Kong Joint Laboratory for Immunity and Genetics of Chronic Kidney Disease, The Chinese University of Hong Kong, Hong Kong, China
Renal fibrosis is one of the most characterized pathological features in chronic kidney disease (CKD). Progressive fibrosis eventually leads to renal failure, leaving dialysis or allograft transplantation the only clinical option for CKD patients. Transforming growth factor-beta (TGF-beta) is the key mediator in renal fibrosis and is an essential regulator for renal inflammation. Therefore, the general blockade of the pro-fibrotic TGF-beta may reduce fibrosis but may risk promoting renal inflammation and other side effects due to the diverse role of TGF-beta in kidney diseases. Long non-coding RNAs (lncRNAs) are RNA transcripts with more than 200 nucleotides and have been regarded as promising therapeutic targets for many diseases. This review focuses on the importance of TGF-beta and lncRNAs in renal inflammation, fibrogenesis, and the potential applications of TGF-beta and lncRNAs as the therapeutic targets and biomarkers in renal fibrosis and CKD are highlighted.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81903956, 81873261]; Guangdong-Hong Kong-Macao-Joint Labs Program from Guangdong Science and Technology [2019B121205005]; Research Grants Council of Hong KongHong Kong Research Grants Council [GRF 14163317, 14117418, 14104019, R4012-18, C7018-16G]; Lui Che Woo Institute of Innovative Medicine (CARE); Health and Medical Research Fund of Hong Kong [HMRF 05161326, 06173986, 07180516]; Project of Guangdong Province Administration of Traditional Chinese Medicine [20201133]; Basic and Applied Basic Research Project of Guangzhou Science and Technology Department [202102020011]
第一作者机构：[1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China[2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
通讯作者：
通讯机构：[2]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China[5]Guangdong-Hong Kong Joint Laboratory for Immunity and Genetics of Chronic Kidney Disease, The Chinese University of Hong Kong, Hong Kong, China
推荐引用方式(GB/T 7714)：
Gu Yue-Yu,Dou Jing-Yun,Huang Xiao-Ru,et al.Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis[J].FRONTIERS IN PHYSIOLOGY.2021,12:doi:10.3389/fphys.2021.684236.
APA：
Gu, Yue-Yu,Dou, Jing-Yun,Huang, Xiao-Ru,Liu, Xu-Sheng&Lan, Hui-Yao.(2021).Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis.FRONTIERS IN PHYSIOLOGY,12,
MLA：
Gu, Yue-Yu,et al."Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis".FRONTIERS IN PHYSIOLOGY 12.(2021)
