机构：[1]Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou 510515, China[2]Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China浙江大学医学院附属第一医院[3]Division of Nephrology, Changzheng Hospital, Shanghai, China[4]Department of Nephrology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[5]Department of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China[6]Department of Nephrology, The 8th Medical Center of Chinese, PLA General Hospital, Beijing, China[7]Departmentof Nephrology, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangzhou, China广东省中医院[8]Department of Nephrology, Xijing Hospital, Xi’an, China.
The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in hemodialysis (HD) patients.A total of 1394 maintenance HD patients with complete data on AOPP and related parameters were included from China Collaborative Study on Dialysis (CCSD), a multi-center, prospective cohort study. The primary outcome was all-cause mortality, the secondary outcome was cardiovascular disease (CVD) mortality.During a median follow-up duration of 5.2 years (IQR, 2.1-5.4), all-cause mortality occurred in 492 (31.4%) participants. Overall, there was a reversed L-shaped association between serum AOPP and all-cause mortality in HD patients (P for nonlinearity = 0.04), with an inflection point at 87 µmol/L. Accordingly, there was no significant association between serum AOPP and all-cause mortality (per SD increment; HR, 0.94; 95%CI, 0.84, 1.05) in participants with AOPP < 87 µmol/L. However, there was a positive relationship of serum AOPP and all-cause mortality (per SD increment; HR, 1.24; 95%CI, 1.08, 1.42) in those with AOPP ≥ 87 µmol/L. Moreover, a similar trend was found for CVD mortality.Elevated serum AOPP levels were associated with higher risk of all-cause mortality in Chinese maintenance HD patients.
基金：
National Natural Science Foundation of China
(82070790 to J.P.J), the Nature Science Foundation of Guangdong Province
(2014A030313345 to J.P. J), the Clinical Innovation Research Program of
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
(2018GZR0201003 to F.F.H.), the Research Fund Program of Guangdong Provincial
Key Laboratory of Renal Failure Research (2017B030314036 to F.F.H.), the
Major International (Regional) Joint Research Project (81620108003 to F.F.H.),
and the National Innovation Team Program (81521003 to Y.H.L).
第一作者机构：[1]Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangdong Provincial Institute of Nephrology, Guangzhou 510515, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Chun,Zhang Yuanyuan,Chen Jianghua,et al.Association between serum advanced oxidation protein products and mortality risk in maintenance hemodialysis patients.[J].JOURNAL OF TRANSLATIONAL MEDICINE.2021,19(1):doi:10.1186/s12967-021-02960-w.
APA：
Zhou Chun,Zhang Yuanyuan,Chen Jianghua,Mei Changlin,Xiong Fei...&Hou Fan Fan.(2021).Association between serum advanced oxidation protein products and mortality risk in maintenance hemodialysis patients..JOURNAL OF TRANSLATIONAL MEDICINE,19,(1)
MLA：
Zhou Chun,et al."Association between serum advanced oxidation protein products and mortality risk in maintenance hemodialysis patients.".JOURNAL OF TRANSLATIONAL MEDICINE 19..1(2021)
医学