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Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis.

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收录情况： ◇ SCIE

作者：
Huang Zifeng[1,2] * ; Si Wenwen[1] * ; Li Xinrong[1,2] ; Ye Shanyu[3] ; Liu Xuelei[1] ; Ji Yichun[4] ; Hao Xiaoqian[1,2] ; Chen Dongfeng[3] ; Zhu Meiling[1] ;
机构： [1]Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong 518104, China [2]Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China [3]Department of Anatomy, )e Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China [4]Shenzhen Bao An Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China
出处：
DOI： 10.1155/2021/6668249
ISSN：

摘要：
Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson's disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxidase 4 (GPX4) and Ferritin Heavy Chain 1 (FTH1), the level of reactive oxygen species (ROS), and the morphology of mitochondrial were detected to evaluate the level of ferroptosis. The results showed that moxibustion treatment of Shi's moxa sticks could reduce the behavioral score, alleviate the level of ferroptosis, decrease mitochondrial damage, and improve dopaminergic neuron survival. In conclusion, the present study results indicated that Shi's moxa sticks could effectively suppress the level of ferroptosis, thereby improving the survival of dopaminergic neurons in the SNpc of PD rats, which may provide a promising complementary and alternative therapy for PD patients.Copyright © 2021 Zifeng Huang et al.

基金：
Traditional Chinese Medicine Bureau of Guangdong Province, China (grant no. 20203010), the Natural Science Foundation of Guangdong Province (grant no. 2020A151501325), the Shenzhen Science and Technology Innovation Committee Subject (grant no. JCYJ20190807112405520), the Bao'an TCM Development Foundation (grant nos. 2020KJCX-KTYJ-130 and 2020KJCX-KTYJ-131), and the Joint Research Project of Guangdong Academy of Traditional Chinese Medicine (grant no. 2017A020213036).
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外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 4 区 医学
小类 | 3 区 全科医学与补充医学
最新[2025]版：
无
JCR分区：
出版当年[2019]版：
Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
最新[2023]版：
无

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong 518104, China [2]Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Zifeng,Si Wenwen,Li Xinrong,et al.Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis.[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2021,2021:doi:10.1155/2021/6668249.
APA：
Huang Zifeng,Si Wenwen,Li Xinrong,Ye Shanyu,Liu Xuelei...&Zhu Meiling.(2021).Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis..EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,
MLA：
Huang Zifeng,et al."Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis.".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021.(2021)

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