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Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species.

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资源类型：
Pubmed体系：
作者：
Chen Delong[1,2] * ; Wang Qingqing[3] * ; Li Ying[4] * ; Sun Ping[5] ; Kuek Vincent[2] ; Yuan Jinbo[2] ; Yang Junzheng[6] ; Wen Longfei[1] ; Wang Haibin[7] ; Xu Jiake[2] ; Chen Peng[7] ;
机构： [1]Department of Orthopaedic Surgery, Clifford Hospital, Jinan University, Guangzhou, China [2]School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia [3]Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China [4]Department of Orthopaedic Surgery, Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China [5]Department of Endocrinology, First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China [6]Guangzhou University of Chinese Medicine, Guangzhou, China [7]Department of Orthopaedic Surgery, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
出处：
DOI： 10.3389/fphar.2021.664836
ISSN：

关键词： notopterol osteoclastogenesis osteoporosis nfatc1 ROS

摘要：
Integrity of the skeleton is sustained through the balanced activities of osteoblasts and osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts activation commonly seen in osteoporosis. Notopterol (NOT) is a main component of Notopterygium incisum which exerts a wide spectrum effect on biomedical pharmacology. In our study, we found NOT serves as an inhibitor in regulating RANKL-activated osteoclasts formation and bone resorption function by calculating tartrate resistant acid phosphatase (TRAcP) staining and hydroxyapatite resorption assays. Furthermore, RANKL-mediated signaling pathways including MAPK, NF-κB and calcium ossification were hampered, whereas ROS scavenging enzymes in Nrf2/Keap1/ARE signaling pathways were promoted by NOT. In addition, the activation of the essential transcription factor NFATc1 in RANKL-mediated osteoclastogenesis was almost totally suppressed by NOT. What is more, NOT diminished the loss of bone mass in preclinical model of OVX mice by blocking osteoclastogenesis determined by bone histomorphometry, TRAcP staining and H&E staining. Conclusively, our findings demonstrated that NOT could arrest osteoclastogenesis and bone resorptive activity by attenuating RANKL-mediated MAPK, NF-κB, calcium and NFATc1 signaling transduction pathways and enhancing ROS scavenging enzymes in Nrf2/Keap1/ARE pathways in vitro, and prohibit bone loss induced by OVX in vivo. Taken together, NOT may be identified to be a natural and novel treatment for osteolytic diseases.Copyright © 2021 Chen, Wang, Li, Sun, Kuek, Yuan, Yang, Wen, Wang, Xu and Chen.

基金：
Funder: Australian Health and Medical Research Council Host: JX Number: 1107828, 1027932, 1127156 Funder: National Natural Science Foundation of China Host: HW Number: 81774339, 82074462 Funder: National Natural Science Foundation of China Host: PC Number: 81603641 Funder: National Natural Science Foundation of China Host: PS Number: 81704098 Funder: Guangdong Provincial Science and Technology Project Host: PC Number: 2017A020213030 Funder: 2019 Key Research of Guangzhou University of Chinese Medicine Host: HW Number: XK201912 Funder: Project of Administration of Traditional Chinese Medicine of Guangdong Province of China Host: YL Number: 20201318
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 药学
第一作者：
第一作者机构： [1]Department of Orthopaedic Surgery, Clifford Hospital, Jinan University, Guangzhou, China [2]School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Delong,Wang Qingqing,Li Ying,et al.Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species.[J].Frontiers in pharmacology.2021,12:664836.doi:10.3389/fphar.2021.664836.
APA：
Chen Delong,Wang Qingqing,Li Ying,Sun Ping,Kuek Vincent...&Chen Peng.(2021).Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species..Frontiers in pharmacology,12,
MLA：
Chen Delong,et al."Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species.".Frontiers in pharmacology 12.(2021):664836

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