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Spontaneous fundus lesions in elderly monkeys: An ideal model for age-related macular degeneration and high myopia clinical research.

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收录情况： ◇ SCIE ◇ 预警期刊

作者：
Zeng Baozhu[1] * ; Zhang Hening[1] ; Peng Yuting[2] ; Yu Huan[1] ; Li Weihua[1] ; Li Zhiquan[1] ; Xie Yaojue[1] ; Qiu Sujuan[1] ; Wu Peixin[1] ; Zhang Wang[1] ; Liu Yanwei[3] ; Chen Yanming[4] ; Liu Xing[1,*1] ; Huang Bing[1,*1] ;
机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China [2]Department of Ophthalmology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [3]Chuangyao Biotechnology Co., Ltd., Zhaoqing, China [4]Xiangguan Biotechnology Co., Ltd., Guangzhou, China
出处：
DOI： 10.1016/j.lfs.2021.119811
ISSN：

关键词： Animal model Fundus diseases Age-related macular degeneration High myopia Cynomolgus monkeys

摘要：
Age-related macular degeneration (AMD) and high myopia are frequent causes of progressive visual impairment, so it is critical to identify animal models with resembling human retinal physiology, AMD and high myopia pathological features for therapeutic studies.We screened elderly cynomolgus monkeys for fundus lesions by slit-lamp biomicroscope combined with fundus pre-set lens and further examined positive cases by color fundus photography (CFP), optical coherence tomography (OCT), fundus fluorescein angiography (FFA), streak retinoscopy, and A-scan ultrasonography.Among the 156 animals examined, 10 males and 5 females (30 eyes) exhibited fundus abnormalities (9.6% prevalence). Multi-modal imaging revealed drusen in 20 eyes of 11 animals (prevalence rate of 7.1%), tessellated fundus in 22 eyes of 11 animals, and myopia choroidal neovascularization (CNV) in 4 eyes of 3 animals.Aged cynomolgus monkeys exhibit spontaneous fundus lesions resembling human AMD and high myopia, which could be an ideal model for clinical research.Copyright © 2021. Published by Elsevier Inc.

基金：
Fundamental Research Funds of the State Key Laboratory of Ophthalmology (Guangzhou, China) [grant numbers 303060202400201018 and 303010303018], and the Science and Technology Planning Project of Guangdong Province, China [grant numbers 2019A030317002 and 2017A030303013].
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学 3 区 医学：研究与实验
JCR分区：
出版当年[2019]版：
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
通讯作者：
通讯机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China [*1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China.
推荐引用方式(GB/T 7714)：
Zeng Baozhu,Zhang Hening,Peng Yuting,et al.Spontaneous fundus lesions in elderly monkeys: An ideal model for age-related macular degeneration and high myopia clinical research.[J].LIFE SCIENCES.2021,282:doi:10.1016/j.lfs.2021.119811.
APA：
Zeng Baozhu,Zhang Hening,Peng Yuting,Yu Huan,Li Weihua...&Huang Bing.(2021).Spontaneous fundus lesions in elderly monkeys: An ideal model for age-related macular degeneration and high myopia clinical research..LIFE SCIENCES,282,
MLA：
Zeng Baozhu,et al."Spontaneous fundus lesions in elderly monkeys: An ideal model for age-related macular degeneration and high myopia clinical research.".LIFE SCIENCES 282.(2021)

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