机构：[1]Intensive Care Unit．Guangdong ProvincaI Hospital of TraditionaI Chinese Medicine，Guangzhou(51 0006)，China[2]Intensive Care Unit．Wuhan HospitaI of TraditionaI Chinese Medicine。Wuhan(430000),China
Objective：To evaluate the efect of electro-acupuncture on Zusanli(ST 36)，Guanyuan(RN 4)
in patients with sepsis．and explore its mechanism in term of immune regulation．M ethods：In this prospective
randomized controlled trial，60 patients with sepsis were randomly assigned to the control group and the
intervention group equally by block randomization．Patients in the control group received routine treatment
and those in the intervention group received electro-acupuncture at bilateraI Zusanli and Guanyuan in addition
to routine treatment，respectively．The mortality at 28 days，Acute Physiology and Chronic Health Evaluation
(APACHE)-11 score were compared to evaluate the efect，and the Ievels of T celI subsets(CD3+，CD4+，CD8+，
CD4+／CD8+)and monocytes of human leukocyte antigen(HLA)-DR using flow cytometry were compared
to explore the mechanism of this combined treatment．Results：Fifty-eight Patients completed the tria1 with
29 in each group．There was no significant diference of mortality in the 28th day between the tw o groups．
with 5 death 0f 29 patients in the intervention group(1 7_2％)and 9 of 29 in the controI group(31．0％)．After
treatment。APACHE-11 score of both groups was significantly decreased，however，score of the intervention
group was Iower than the controI group(13．28±7．07 vs．17．10±5．83；P<O．01)．The Ievels of CD3+，CD4+，
CD8+ and CD4+，CD8+ ratio of the intervention group improved after treatment and were higher than the
controI group f59．71％ ±11．94％ vs．52．54％ ±11．86％：36．46％ ±7．60％ vS．31．58％ ±10．23％ ；18．40％ ±8．82％
vs．23．07％ ±7．30％：2．38±1．14 vs．1．54±0．80，respectively；all P<O．05)．The expression of HLA-DR
significantly increased after treatment in the intervention group than that in the controI group(7．28％ ±9．26％
ys．1．27％ ±7．00％：P<0．01)．Conclusion：Electro-acupuncture at Zusanli and Guanyuan could improve clinicaI
curative efect in patients with sepsis．which might be achieved by regulation of the immune system．
第一作者机构：[1]Intensive Care Unit．Guangdong ProvincaI Hospital of TraditionaI Chinese Medicine，Guangzhou(51 0006)，China
通讯作者：
推荐引用方式(GB/T 7714)：
YANG Guang,HU Rui-ying,DENG Airjing,et al.Effects of Electro-Acupuncture at Zusanli,Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation[J].CHINESE JOURNAL OF INTEGRATIVE MEDICINE.2016,22(3):219-224.doi:10.1007/s11655-016-2462-9.
APA：
YANG Guang,HU Rui-ying,DENG Airjing,HUANG Yu&LIJian.(2016).Effects of Electro-Acupuncture at Zusanli,Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,22,(3)
MLA：
YANG Guang,et al."Effects of Electro-Acupuncture at Zusanli,Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 22..3(2016):219-224
