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Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ EI

作者：
Liu, Huazhen[1] * ; Chen, Yonger[2] * ; Wen, Yifan[2] ; Zhu, Shumin[2] ; Huang, Song[2] ; He, Lian[3] ; Hou, Shaozhen[2] ; Lai, Xiaoping[2] ; Chen, Shuxian[4,*1] ; Dai, Zhenhua[1,*2] ; Liang, Jian[2,5,*3,*4] ;
机构： [1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510405, China [2]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510006, P. R. China [3]Guangdong Food and Drug Vocational College, Guangdong, Guangzhou 510520, P. R. China [4]The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, Guangzhou 510080, China [5]Dongguan Institute of Guangzhou University of Chinese Medicine, Guangdong, Dongguan 523808, P. R. China
出处：
DOI： 10.1021/acs.jafc.1c01645
ISSN：

关键词： mTORC1 NAFLD phloridzin Treg SREBP-1c

摘要：
We aimed to investigate whether phloridzin could alleviate nonalcoholic fatty liver disease (NAFLD) in mice, which was induced by feeding a high-fat diet (HFD). We initially analyzed the effect of phloridzin on alleviating HFD-induced NAFLD in CS7BL/6J mice and oleic acid (OA)-stimulated human normal liver L-02 cells (L02). Then, we investigated the mechanism of phloridzin on the mTORC1/sterol-regulatory element-binding protein-1c (SREBP-1c) signaling pathway by siRNA analysis, qRT-PCR, flow cytometry, and western blot analysis in vivo and in vitro. The results revealed that phloridzin significantly inhibited the increase in body weight, alleviated abnormal lipid metabolism, and decreased lipid biosynthesis and insulin resistance. Moreover, phloridzin augmented the number of CD8(+)CD122(+)PD-1(+) Tregs and CD4(+)FoxP3(+) Tregs in HFD-fed CS7BL/6J mice and HFD-fed aP2-SREBF1c mice and downregulated the mTORC1/SREBP-1c signaling pathway-related protein expressions in vivo and in vitro. Furthermore, phloridzin reduced the expression of SREBP-1c in SREBP-1c-RNAi-lentivirus-transfected L02 cells and reversed the SREBP-1c expression in HFD-fed aP2-SREBF1c transgenic mice. Phloridzin ameliorates lipid accumulation and insulin resistance via inhibiting the mTORC1/SREBP-1c pathways. These results indicated that phloridzin may actively ameliorate NAFLD.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82004025]; Natural Science Foundation of Guangdong Province ChinaNational Natural Science Foundation of Guangdong Province [2019A1515012082, 2020A1515011023]; Foundation and Application Foundation Project of Guangdong Province [2019A1515110561]; Guangdong Province Universities and Colleges; Special Funds from Central Finance of China in Support of the Development of Local Colleges and University [A1-AFD018181Z3961, A1-AFD01515A03, A1-AFD016151Z3207]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 农林科学
小类 | 1 区 农业综合 2 区 应用化学 2 区 食品科技
最新[2025]版：
大类 | 1 区 农林科学
小类 | 1 区 农业综合 2 区 应用化学 2 区 食品科技
JCR分区：
出版当年[2019]版：
Q1 CHEMISTRY, APPLIED Q1 AGRICULTURE, MULTIDISCIPLINARY Q1 FOOD SCIENCE & TECHNOLOGY
最新[2023]版：
Q1 AGRICULTURE, MULTIDISCIPLINARY Q1 CHEMISTRY, APPLIED Q1 FOOD SCIENCE & TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510405, China
共同第一作者：
通讯作者：
通讯机构： [1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510405, China [2]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510006, P. R. China [4]The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, Guangzhou 510080, China [5]Dongguan Institute of Guangzhou University of Chinese Medicine, Guangdong, Dongguan 523808, P. R. China [*1]The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, Guangzhou 510080, China [*2]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510405, China [*3]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510006, P. R. China [*4]Dongguan Institute of Guangzhou University of Chinese Medicine, Guangdong, Dongguan 523808, P. R. China
推荐引用方式(GB/T 7714)：
Liu Huazhen,Chen Yonger,Wen Yifan,et al.Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway[J].JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2021,69(31):8671-8683.doi:10.1021/acs.jafc.1c01645.
APA：
Liu, Huazhen,Chen, Yonger,Wen, Yifan,Zhu, Shumin,Huang, Song...&Liang, Jian.(2021).Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69,(31)
MLA：
Liu, Huazhen,et al."Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69..31(2021):8671-8683

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