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Advances in cell death - related signaling pathways in acute-on-chronic liver failure.

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收录情况： ◇ SCIE

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机构： [1]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China. [2]The First Affiliated Hospital, Guangzhou TCM University, Guangzhou, China, 510006. [3]Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China. [4]School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China, 510006. [5]Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China

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Acute-on-chronic liver failure (ACLF) has been a hot spot in the field of liver disease research in recent years, with high morbidity, rapid course change and high mortality. Currently, there is the absence of specific treatment in clinical practice. Liver transplantation has the best therapeutic effect, but it is prone to have internal environment disorder and liver cell death after transplantation, which leads to the failure of transplantation.In recent years, with the development of molecular biology, scholars have explored the treatment of ACLF at the molecular level, and more and more molecular signaling pathways related to the treatment of ACLF have been discovered. Modulating the relevant signaling pathways to reduce the mortality of liver cells after transplantation may effectively improve the success rate of transplantation. In this review, we introduce some signaling pathways related to cell death and their research progress in acute-on-chronic liver failure.Copyright © 2021 Elsevier Ltd. All rights reserved.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区胃肠肝病学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区胃肠肝病学

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出版当年[2020]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q2 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 2.947 出版当年[2020版] 2.954 出版当年五年平均 2.718 出版前一年[2019版] 3.189 出版后一年[2021版]

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第一作者机构： [5]Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China

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