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Trans-ethnic genome-wide association study of severe COVID-19

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu, Peng[1,2] * ; Ding, Lin[3,4] * ; Li, Xiaodong[5,6] * ; Liu, Siyang[7] * ; Cheng, Fanjun[8] * ; He, Qing[9] * ; Xiao, Mingzhong[5,6] ; Wu, Ping[1,2] ; Hou, Hongyan[2,10] ; Jiang, Minghui[3,4] ; Long, Pinpin[4,11] ; Wang, Hao[4,11] ; Liu, Linlin[12] ; Qu, Minghan[3,4] ; Shi, Xian[3,4] ; Jiang, Qin[4,11] ; Mo, Tingting[4,11] ; Ding, Wencheng[1,2] ; Fu, Yu[1,2] ; Han, Shi[12] ; Huo, Xixiang[12] ; Zeng, Yingchun[12] ; Zhou, Yana[5,6] ; Zhang, Qing[5,6] ; Ke, Jia[5,6] ; Xu, Xi[5,6] ; Ni, Wei[5,6] ; Shao, Zuoyu[5,6] ; Wang, Jingzhi[5,6] ; Liu, Panhong[13] ; Li, Zilong[13] ; Jin, Yan[14] ; Zheng, Fang[15] ; Wang, Fang[9] ; Liu, Lei[9] ; Li, Wending[4,11] ; Liu, Kang[4,11] ; Peng, Rong[4,11] ; Xu, Xuedan[4,11] ; Lin, Yuhui[4,11] ; Gao, Hui[4,11] ; Shi, Limei[4,11] ; Geng, Ziyue[4,11] ; Mu, Xuanwen[4,11] ; Yan, Yu[3,4] ; Wang, Kai[3,4] ; Wu, Degang[3,4] ; Hao, Xingjie[3,4] ; Cheng, Shanshan[3,4] ; Qiu, Gaokun[4,11] ; Guo, Huan[4,11] ; Li, Kezhen[1,2] ; Chen, Gang[1,2] ; Sun, Ziyong[2,10] ; Lin, Xihong[16,17,18] ; Jin, Xin[19] ; Wang, Feng[2,10] ; Sun, Chaoyang[1,2] ; Wang, Chaolong[2,3,4] ;
机构： [1]Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [2]National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China [3]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [4]Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating),School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [5]Hepatic Disease Institute,Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital ofTraditional Chinese Medicine, Wuhan, China [6]Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China [7]School of PublicHealth (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China [8]Department of Hematology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, China [9]The Third People’s Hospital of Shenzhen, National Clinical Research Center forInfectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China [10]Department ofLaboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [11]Department ofOccupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [12]Hubei Provincial Center for Disease Control and Prevention, Wuhan, China [13]College of Life Sciences, University of ChineseAcademy of Sciences, Beijing, China [14]Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science andTechnology, Wuhan, China [15]Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [16]Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA [17]Department of Statistics, HarvardUniversity, Cambridge, MA, USA [18]Broad Institute of MIT and Harvard, Cambridge, MA, USA [19]School of Medicine, South China University ofTechnology, Guangzhou, China
出处：
DOI： 10.1038/s42003-021-02549-5
ISSN：

摘要：
COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. We identified three significant signals outside the well-established 3p21.31 locus: an intronic variant in FOXP4-AS1 (rs1853837, odds ratio OR = 1.28, P = 2.51 x 10(-10), allele frequencies in Chinese/European AF = 0.345/0.105), a frameshift insertion in ABO (rs8176719, OR = 1.19, P = 8.98 x 10(-9), AF = 0.422/0.395) and a Chinese-specific intronic variant in MEF2B (rs74490654, OR = 8.73, P = 1.22 x 10(-8), AF = 0.004/0). These findings highlight an important role of the adaptive immunity and the ABO blood-group system in protection from developing severe COVID-19. Chaolong Wang and colleagues report a large genome-wide association study for COVID-19 severity in Chinese individuals. By meta-analysis with European data, they identify 3 loci associated with severe disease that suggest key roles for the adaptive immune system and the ABO blood group system in development of severe COVID-19.

基金：
Wuhan Municipal Health Commission [EG20B03]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973148, 82003561, 32000398, 31900487]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2017A030306026]; Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases [2019B121205005]

基金编号： EG20B03 81973148 82003561 32000398 31900487 2017A030306026 2019B121205005

语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 生物
小类 | 2 区 生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生物学
JCR分区：
出版当年[2019]版：
Q1 BIOLOGY
最新[2023]版：
Q1 BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [2]National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [2]National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, China [3]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China [4]Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating),School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [10]Department ofLaboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
推荐引用方式(GB/T 7714)：
Wu Peng,Ding Lin,Li Xiaodong,et al.Trans-ethnic genome-wide association study of severe COVID-19[J].COMMUNICATIONS BIOLOGY.2021,4(1):doi:10.1038/s42003-021-02549-5.
APA：
Wu, Peng,Ding, Lin,Li, Xiaodong,Liu, Siyang,Cheng, Fanjun...&Wang, Chaolong.(2021).Trans-ethnic genome-wide association study of severe COVID-19.COMMUNICATIONS BIOLOGY,4,(1)
MLA：
Wu, Peng,et al."Trans-ethnic genome-wide association study of severe COVID-19".COMMUNICATIONS BIOLOGY 4..1(2021)

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