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Healthy Lifestyle and Mortality Among Adults Receiving Hemodialysis: The DIET-HD Study.

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机构: [1]National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou city, Guangdong Province, China [2]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou city, Guangdong Province, China [3]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [4]European Renal Nutrition Working Group of the European Renal Association–European Dialysis Transplant Association (ERA-EDTA). [5]Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, NSW 2006, Australia [6]Department of Emergency and Organ Transplantation, University of Bari, Bari, Piazza Giulio Cesare, 70124 Bari, Italy [7]Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, NSW, Australia [8]College of Medicine and Public Health, Flinders University, Adelaide, Australia [9]Division of Nephrology, Department of Clinical Sciences, Lund University, Lund, Sweden
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关键词: Lifestyle diet physical activity body mass index smoking blood pressure mortality hemodialysis cohort DIET-HD

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A healthy lifestyle promotes cardiovascular health and reduces cardiac-related mortality in the general population but its benefits for people receiving maintenance hemodialysis are uncertain.Prospective cohort study.5,483 of 9,757 consecutive adults receiving maintenance hemodialysis (January 2014 to June 2017, median dialysis vintage: 3.6 yrs) in a multinational private dialysis network and with complete lifestyle data.Based on the American Heart Association's recommendations for cardiovascular prevention, a modified healthy lifestyle score was the sum of four components addressing use of smoking tobacco, physical activity, diet, and control of systolic blood pressure.Cardiovascular and all-cause mortality.Adjusted proportional hazards (aHRs) regression analyses with country as a random effect to estimate the associations between lifestyle score (low [0-2 points] as the referent, medium [3-5], and high [6-8]) and mortality. Associations were expressed as aHRs with 95% confidence intervals (CIs).During a median of 3.8 years (17,451 person-years in total), there were 2,163 deaths, of which 826 were related to cardiovascular disease. Compared to patients with a low lifestyle score, the aHRs (95% CIs) for all-cause mortality among those with medium and high lifestyle scores were 0.75 (0.65-0.85) and 0.64 (0.54-0.76), respectively. Compared to patients with a low lifestyle score, the aHRs (95% CIs) for cardiovascular mortality among those with medium and high lifestyle scores were 0.73 (0.59-0.91) and 0.65 (0.49-0.85), respectively.Self-reported lifestyle, data-driven approach.A healthier lifestyle is associated with lower all-cause and cardiovascular mortality among patients receiving maintenance hemodialysis.Copyright © 2021. Published by Elsevier Inc.

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大类 | 1 区 医学
小类 | 1 区 泌尿学与肾脏学
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大类 | 1 区 医学
小类 | 1 区 泌尿学与肾脏学
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出版当年[2020]版:
Q1 UROLOGY & NEPHROLOGY
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Q1 UROLOGY & NEPHROLOGY

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第一作者机构: [1]National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou city, Guangdong Province, China [2]Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou city, Guangdong Province, China [3]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [4]European Renal Nutrition Working Group of the European Renal Association–European Dialysis Transplant Association (ERA-EDTA).
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通讯机构: [5]Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, NSW 2006, Australia [6]Department of Emergency and Organ Transplantation, University of Bari, Bari, Piazza Giulio Cesare, 70124 Bari, Italy [*1]Department of Emergency and Organ Transplantation University of Bari Piazza Giulio Cesare 70124 Bari, Italy
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