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Novel MRI technique for the quantification of biochemical deterioration in steroid-induced osteonecrosis of femoral head: a prospective diagnostic trial.

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机构： [1]Division of Biomedical Engineering, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China, [2]Department of Radiology, Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Science, Guangzhou, Guangdong 510080, China, [3]Traumatology and Orthopedics Institute, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China, [4]Department of Orthopedic, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China, [5]Division of Orthopedic Surgery, University of Alberta, Edmonton, Alberta T6G 2R3, Canada, [6]Department of Radiology, Guangzhou First People’s Hospital/the Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong, 510180, China, [7]Department of Endocrinology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China

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To explore the novel magnetic resonance imaging techniques, IVIM-DWI and IDEAL-IQ in detecting bone marrow fat and microcirculation in steroid-induced osteonecrosis of the femoral head (SIONFH). In this prospective study, 49 patients (80 hips) with SIONFH taking glucocorticoids and 24 healthy volunteers (48 hips) were recruited and assessed by T1WI, T2WI/fs, IDEAL-IQ and IVIM-DWI. The affected hips, contralateral asymptomatic hips and normal hips, as well as normal, penumbra and necrotic areas in the affected hips, were classified and evaluated. Imaging results were compared with histologic bone sections obtained from SIONFH patients undergoing surgery. The fat fraction (FF) and perfusion fraction (f) differences between groups were analyzed using analysis of variance, the LSD t-test, Pearson correlation analysis and ROC curve analysis. Our results demonstrate that IDEAL-IQ (FF) and IVIM-DWI (f) enable the classification of SIONFH at different ARCO stages. The FF was positively associated with the progression of the disease (r = 0.72), in contrast to f (r = -0.17). The FF and f were significantly different among the necrotic, penumbra and normal areas, and they were negatively correlated with each other (r = -0.37). The diagnostic sensitivity and specificity of IDEAL-IQ were 96.9% and 86.7%, and those of IVIM-DWI were 72.34% and 58.33%, respectively. The FF in contralateral asymptomatic hips was significantly higher than in normal hips, but no difference was found for f. IDEAL-IQ, and not IVIM-DWI, was identified to successfully detect bone marrow fat, which is beneficial to the diagnosis of the severity of SIONFH.© The Author(s) 2021. Published by Oxford University Press.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区骨科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区骨科

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出版当年[2019]版：

Q2 ORTHOPEDICS

最新[2023]版：

Q3 ORTHOPEDICS

影响因子： 1.4 最新[2023版] 1.5 最新五年平均 1.917 出版当年[2019版] 0 出版当年五年平均 0 出版前一年[2018版] 1.872 出版后一年[2020版]

第一作者：

第一作者机构： [1]Division of Biomedical Engineering, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China, [2]Department of Radiology, Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Science, Guangzhou, Guangdong 510080, China,

通讯作者：

通讯机构： [1]Division of Biomedical Engineering, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China, [2]Department of Radiology, Guangdong Provincial People’s Hospital/Guangdong Academy of Medical Science, Guangzhou, Guangdong 510080, China,

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