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Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function.

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机构： [1]School of Pharmacy, Changzhou Instituteof Industry and Technology, Changzhou,Jiangsu, People’s Republic of China [2]Longsha Medical Research Institute,Wuxi Hospital of Traditional ChineseMedicine, Wuxi, Jiangsu, People’sRepublic of China [3]School of Pharmacy,Changzhou Institute of Technology,Changzhou, 213022, People’s Republic ofChina [4]Key Laboratory for SoftChemistry and Functional Materials ofMinistry Education, Nanjing University ofScience and Technology, Nanjing, People’sRepublic of China [5]Department ofPharmacy, Guangdong Provincial Instituteof Traditional Chinese Medicine,Guangzhou, People’s Republic of China

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关键词： OA withdrawal morphine-induced rats mice

摘要：

Oleanolic acid (OA) has been shown to be useful for the treatment of mental disorders.In this study, we investigated the effects of OA in animal models of spontaneous withdrawal and naloxone-precipitated withdrawal and evaluated the effects of OA on the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP).OA significantly improved symptoms of withdrawal, and significantly reduced the acquisition and reinstatement of morphine-induced conditioned place preference. Moreover, OA significantly reduced the serum content of 5-hydroxy tryptamine (5-HT) and dopamine (DA) in a dose-dependent manner, and reduced norepinephrine (NE) and 5-HT content in the frontal cortex (PFC), while significantly increasing endorphin content in rats. OA also significantly reduced serum DA content in mice.These results indicate that OA can improve the withdrawal symptoms of rats and mice by regulating the DA system and suggest that OA may be useful in treatment of morphine addiction.© 2021 Shi et al.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药物化学 2 区药学

第一作者：

第一作者机构： [1]School of Pharmacy, Changzhou Instituteof Industry and Technology, Changzhou,Jiangsu, People’s Republic of China [2]Longsha Medical Research Institute,Wuxi Hospital of Traditional ChineseMedicine, Wuxi, Jiangsu, People’sRepublic of China [*1]School of Pharmacy, Changzhou Institute of Industry and Technology, No. 28#, Mingxin Road, Changzhou, Jiangsu Province, 213164, People’s Republic of China

通讯作者：

通讯机构： [1]School of Pharmacy, Changzhou Instituteof Industry and Technology, Changzhou,Jiangsu, People’s Republic of China [2]Longsha Medical Research Institute,Wuxi Hospital of Traditional ChineseMedicine, Wuxi, Jiangsu, People’sRepublic of China [*1]School of Pharmacy, Changzhou Institute of Industry and Technology, No. 28#, Mingxin Road, Changzhou, Jiangsu Province, 213164, People’s Republic of China [*2]Longsha Medical Research Institute, Wuxi Hospital of Traditional Chinese Medicine, No. 8#, Zhongnan Road, Wuxi, Jiangsu Province, 214071, People’s Republic of China

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