Atherosclerosis is the pathophysiological basis of circulatory system diseases. Inflammation is not only a key indicator, but is also the driving force behind these diseases. Atherosclerosis is therefore treated using anti-inflammatory strategies. Chinese herbal medicine is widely used in Asia, China in particular. Naosuikang is a Chinese herbal medicine that has been used clinically, and its clinical efficacy has been confirmed, but its specific mechanism needs further clarification. Exosomes are the transmitters of signals between cells, and they participate in the occurrence and development of inflammation. We hypothesized that Naosuikang uses exosomal microRNA (miRNA) in its role as a treatment for atherosclerosis. In this project, we used atherosclerotic mice as an animal model, treating them with various doses of Naosuikang and observing the external effects of miRNAs on the body. This research will provide insight into the mechanism of action of Naosuikang.