机构：[1]Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, Jilin, People’s Republic of China[2]The Second Clinical School of Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine‑Zhuhai Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China珠海院区广东省中医院
Eupafolin is a flavonoid that can be extracted from common sage. Previous studies have reported that Eupafolin has antioxidant, anti-inflammatory and anti-tumor properties. However, no studies have investigated the role of Eupafolin in breast cancer. Herein, we investigated the effect of Eupafolin on two human breast cancer cell lines, as well as its potential mechanism of action. Next, the data showed that proliferation, migration and invasion ability of breast cancer cells that were treated with Eupafolin was significantly reduced, while the apoptosis rate was significantly increased. In addition, Eupafolin treatment caused breast cancer cell proliferation to be blocked in the S phase. Moreover, Eupafolin significantly induced autophagy in breast cancer cells, with an increase in the expression of LC3B-II. PI3K/AKT, MAPKs and NF-kappa B pathways were significantly inhibited by Eupafolin treatment. Additionally, 3-MA (a blocker of autophagosome formation) significantly reduced Eupafolin-induced activation of LC3B-II in breast cancer cells. Furthermore, Eupafolin displayed good in vitro anti-angiogenic activity. Additionally, anti-breast cancer activity of Eupafolin was found to be partially mediated by Cav-1. Moreover, Eupafolin treatment significantly weakened carcinogenesis of MCF-7 cells in nude mice. Therefore, this data provides novel directions on the use of Eupafolin for treatment of breast cancer.
基金：
Tis work was supported by Jilin Province Science and Technology Development Project (20200703014ZP) and
Natural Science Foundation of Jilin Province (discipline layout project) (20210101364JC)
第一作者机构：[1]Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130062, Jilin, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Wei Jiahui,Ding Yu,Liu Xinmiao,et al.Eupafolin induces apoptosis and autophagy of breast cancer cells through PI3K/AKT, MAPKs and NF-κB signaling pathways[J].SCIENTIFIC REPORTS.2021,11(1):doi:10.1038/s41598-021-00945-9.
APA：
Wei, Jiahui,Ding, Yu,Liu, Xinmiao,Liu, Qing,Lu, Yiran...&Zhang, Jiabao.(2021).Eupafolin induces apoptosis and autophagy of breast cancer cells through PI3K/AKT, MAPKs and NF-κB signaling pathways.SCIENTIFIC REPORTS,11,(1)
MLA：
Wei, Jiahui,et al."Eupafolin induces apoptosis and autophagy of breast cancer cells through PI3K/AKT, MAPKs and NF-κB signaling pathways".SCIENTIFIC REPORTS 11..1(2021)
