The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol.
机构：[1]Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China[2]Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China中山大学附属第一医院[3]Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518132, China深圳市康宁医院深圳医学信息中心中国医学科学院阜外医院深圳医院[4]Department of Rehabilitation Medicine, The Fifth People’s Hospital of Foshan, Foshan 528211, China[5]Department of Traditional Chinese Medicine, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, China
The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period.A total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl-Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging.The results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process.
基金：
This study is supported by the National Key Research and Development Program of China
(grant no.: No.2020YFC2004300; No.2020YFC2004304), National Natural Science Foundation of China
(grants no.: 81971224), 5010 Planning Project of Sun Yat-Sen University of China (No.2014001).
第一作者机构：[1]Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China[2]Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China[2]Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China[3]Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518132, China
推荐引用方式(GB/T 7714)：
Wai-Leung Ambrose Lo,Dandan Chen,Jiangli Zhao,et al.The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol.[J].BRAIN SCIENCES.2021,11(11):doi:10.3390/brainsci11111495.
APA：
Wai-Leung Ambrose Lo,Dandan Chen,Jiangli Zhao,Yan Leng,Ruihao Bian...&Dong-Feng Huang.(2021).The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol..BRAIN SCIENCES,11,(11)
MLA：
Wai-Leung Ambrose Lo,et al."The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol.".BRAIN SCIENCES 11..11(2021)
