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A comprehensive approach to stool donor screening for faecal microbiota transplantation in China.

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机构： [1]School of Medicine, Xiamen University, Xiamen, China [2]Department of Gastroenterology, The First Afliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China [3]Department of Gastroenterology and Hepatology, The Second Hospital of Anhui Medical Univerisity, Hefei, China [4]Department of Gastroenterology, The Fifth People’s Hospital of Shenyang, Shenyang, China [5]Anorectal Diagnosis and Treatment Center,The General Hospital of Xinjiang Military Region, Wulumuqi, China [6]Department of Gastroenterology, Xiangya Hospital, Changsha, China [7]Department of Gastroenterology, Xi’an Central Hospital, Xi’an, China [8]Department of Gastroenterology, The First Afliated Hospital of Bengbu Medical College, Bengbu, China [9]Department of Gastroenterology, The Afliated People’s Hospital of Shanxi Medical University, Taiyuan, China [10]Department of Gastroenterology, Fujian Provincial Hospital, Fuzhou, China [11]Department of Gastroenterology, Pingxiang People’s Hospital, Pingxiang, China [12]Department of Gastroenterology, The Third Afliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China [13]Department of Proctology, The Afliated People’s Hospital of Shanxi Medical University, Taiyuan, China [14]Department of Gastroenterology, 900th Hospital of PLA, Fuzhou, China [15]Department of Gastroenterology, The Second Afliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China [16]Department of Gastroenterology, Jinling Hospital, Nanjing, China [17]Department of Gastroenterology, Afliated Hospital of Zunyi Medical University, Zunyi, China [18]Department of Gastroenterology, The Second Afliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China [19]Xiamen Treatgut Biotechnology Co.,Ltd.,Xiamen, China [20]National Clinical Research Center for Hematologic Diseases, The First Afliated Hospital of Soochow University, Suzhou, China [21]Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China

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关键词： Faecal microbiota transplantation Microbiota evaluation Donor selection Metagenomics Ethical issue

摘要：

Faecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridium difficile infections and chronic gastrointestional infections. However, the risks of FMT and the selection process of suitable donors remain insufficiently characterized. The eligibility rate for screening, underlying microbial basis, and core ethical issues of stool donors for FMT are yet to be elucidated in China.The potential stool donors were screened from December 2017 to December 2019 with the help of an online survey, clinical assessments, and stool and blood testing. Bioinformatics analyses were performed, and the composition and stability of gut microbiota in stool obtained from eligible donors were dynamically observed using metagenomics. Meanwhile, we build a donor microbial evaluation index (DoMEI) for stool donor screening. In the screening process, we also focused on ethical principles and requirements. Of the 2071 participants, 66 donors were selected via the screening process (3.19% success rate). Although there were significant differences in gut microbiota among donors, we found that the changes in the gut microbiota of the same donor were typically more stable than those between donors over time.DoMEI provides a potential reference index for regular stool donor re-evaluation. In this retrospective study, we summarised the donor recruitment and screening procedure ensuring the safety and tolerability for FMT in China. Based on the latest advances in this field, we carried out rigorous recommendation and method which can assist stool bank and clinicians to screen eligible stool donor for FMT.© 2021. The Author(s).

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出版当年[2020]版：

大类 | 2 区工程技术

小类 | 2 区生物工程与应用微生物

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生物工程与应用微生物

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第一作者机构： [1]School of Medicine, Xiamen University, Xiamen, China

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A comprehensive approach to stool donor screening for faecal microbiota transplantation in China.

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