机构：[1]Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, China[2]Shantou University Medical College, Shantou University, Shantou, Guangdong, China[3]Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York, USA[4]College of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, China[5]College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The aim of this article is to get a better insight into the rationale for targeting gut microbiota in T2D treatment. Thus, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms behind the contribution of gut microbiota to T2D pathogenesis. At present, it has become possible to use intestinal microorganism capsules, bacteria liquid, and other preparations to carry out fecal microbiota transplantation for the treatment and intervention of T2D with insulin resistance and immune-mediated Type 1 diabetes (T1D).
基金：
This work was supported by grants from National Health and Health Commission
of the People's Republic of China-NHC Key Laboratory of Health Economics and Policy
Research (No.NHC-HEPR2019003), Shantou Science and Technology Plan medical and
health category project (190923115260372) and Research support project of Longhu
People's Hospital (LHLL2019001), and the fund of 2020 Domestic Visiting Study and
Training Project for Outstanding Young Backbone Talents in Colleges and Universities，No
：gxgnfx202005.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
无
第一作者：
第一作者机构：[1]Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Medical College of Shantou University, Shantou, Guangdong, China[2]Shantou University Medical College, Shantou University, Shantou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York, USA[4]College of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, China[5]College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China[*1]College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, No.1 Huatuo Road, Fuzhou, Fujian, China.[*2]College of Nursing, Anhui University of Chinese Medicine, No.350 Longzihu Road, Hefei, Anhui, China.[*3]Institute for Biotechnology, St. John's University, 8000 Utopia Parkway, Queens, New York, NY, USA.
推荐引用方式(GB/T 7714)：
Kaijian Hou,Shuo Zhang,Zezhen Wu,et al.Reconstruction of intestinal microecology of Type 2 diabetes by fecal microbiota transplantation: Why and how.[J].Bosnian journal of basic medical sciences.2021,doi:10.17305/bjbms.2021.6323.
APA：
Kaijian Hou,Shuo Zhang,Zezhen Wu,Dan Zhu,Fengwu Chen...&Zhe-Sheng Chen.(2021).Reconstruction of intestinal microecology of Type 2 diabetes by fecal microbiota transplantation: Why and how..Bosnian journal of basic medical sciences,,
MLA：
Kaijian Hou,et al."Reconstruction of intestinal microecology of Type 2 diabetes by fecal microbiota transplantation: Why and how.".Bosnian journal of basic medical sciences .(2021)
