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Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile.

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资源类型：
Pubmed体系：
作者：
Lei Zili[1,2,3,*1] * ; Wu Huijuan[1,2,3,4] * ; Yang Yanhong[5] * ; Hu Qing[1,2,3] * ; Lei Yuting[1,2,3] ; Liu Wanwan[1,2,3] ; Nie Ya[1,2,3,4] ; Yang Lanxiang[1,2,3,4] ; Zhang Xueying[1,2,3,4] ; Yang Changyuan[1,2,3,4] ; Lin Ting[1,2,3] ; Tong Fengxue[1,2,3] ; Zhu Jiamin[1,2,3] ; Guo Jiao[1,2,3,*2] ;
机构： [1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China.Institute of Chinese Medicine, Guangdong Pharmaceutical University. Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [2]Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China [3]Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [4]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China [5]The First Affiliated Hospital (School of Clinical Medicine), Guangdong Pharmaceutical University, Nong-Lin-Xia Road 19#, Yue-Xiu District, Guangzhou 510080, PR China
出处：
DOI： 10.1016/j.bmc.2021.116520
ISSN：

摘要：
The increase of concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the serum of postmenopausal women is the important risk factor of the high morbidity of cardiovascular diseases of old women worldwide. To test the anti-hypercholesterolemia function of dihydroartemisinin (DHA) in postmenopausal women, ovariectomized (OVX) mice were generated, and DHA were administrated to OVX mice for 4 weeks. The blood and liver tissues were collected for biochemical and histological tests respectively. The mRNA and protein expression levels of genes related to metabolism and transport of cholesterol, bile acid and fatty acid in the liver or ileum were checked through qPCR and western blot. DHA could significantly reduce the high concentrations of TC and LDL-C in the serum and the lipid accumulation in the liver of ovariectomized mice. The expression of ABCG5/8 was reduced in liver of OVX mice, and DHA could up-regulate the expression of them. Genes of transport proteins for bile salt transport from blood to bile, including Slc10a1, Slco1b2 and Abcb11, were also significantly up-regulated by DHA. DHA also down-regulated the expression of Slc10a2 in the ileum of OVX mice to reduce the absorption of bile salts. Genes required for fatty acid synthesis and uptake, such as Fasn and CD36, were reduced in the liver of OVX mice, and DHA administration could significantly up-regulate the expression of them. These results demonstrated that DHA could improve hypercholesterolemia in OVX mice through enhancing the vectorial transport of cholesterol and bile acid from blood to bile.Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
National Natural Science FoundationNational key R & D plan “Research on modernization of traditional Chinese medicine” (2018YFC1704200); Major basic and applied basic research projects of Guangdong Province of China (2019B030302005); the Guangdong Basic and Applied Basic Research Foundation (2021A1515012383), the Opening Foundation of the Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (KLRB201807); the Science and Technology Planning Project of Guangzhou City (No. 201803010069); and the Science and Technology Project of Yue-Xiu District of Guangzhou (No. 2018-WS-011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 2 区 有机化学 3 区 生化与分子生物学 3 区 药物化学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 有机化学 3 区 生化与分子生物学 3 区 药物化学
第一作者：
第一作者机构： [1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China.Institute of Chinese Medicine, Guangdong Pharmaceutical University. Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [2]Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China [3]Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [*1]Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong TCM Key Laboratory for Metabolic Disease, Guangdong Pharmaceutical University, Wai-Huan-Dong Road 280#, Guangzhou Higher Education Mega Center, Guangzhou 510006 PR China
共同第一作者：
通讯作者：
通讯机构： [1]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine. Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China.Institute of Chinese Medicine, Guangdong Pharmaceutical University. Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [2]Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China [3]Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China [*1]Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong TCM Key Laboratory for Metabolic Disease, Guangdong Pharmaceutical University, Wai-Huan-Dong Road 280#, Guangzhou Higher Education Mega Center, Guangzhou 510006 PR China [*2]280 Wai-Huan-Dong Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China
推荐引用方式(GB/T 7714)：
Lei Zili,Wu Huijuan,Yang Yanhong,et al.Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile.[J].Bioorganic & medicinal chemistry.2022,53:116520.doi:10.1016/j.bmc.2021.116520.
APA：
Lei Zili,Wu Huijuan,Yang Yanhong,Hu Qing,Lei Yuting...&Guo Jiao.(2022).Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile..Bioorganic & medicinal chemistry,53,
MLA：
Lei Zili,et al."Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile.".Bioorganic & medicinal chemistry 53.(2022):116520

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