Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial
机构：[1]The Secondary Medical College, Guangzhou University of Traditional Chinese Medicine, 111 Dade Road, Guangzhou 510120, People’s Republic of China.[2]Guangzhou University of Traditional Chinese Medicine, 12 Jichang Road, Guangzhou 510006, People’s Republic of China.
BackgroundAcupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote from pain areas. Therefore, the aim of this study is to investigate the analgesic effect of electroacupuncture (EA) at homotopic or heterotopic acupoints on abdominal pain in patients with IBS.Methods/designThis study is a randomized, single-blinded, controlled, four-arm parallel trial. A total of 144patients will be randomly assigned to four groups: a homotopic noxious stimulation group (group A), a homotopic innocuous stimulation group (group B), a heterotopic noxious stimulation group (group C), and a heterotopic innocuous stimulation group (group D). Each patient will receive 14 sessions of treatment, twice per week for 7weeks. The primary outcome will be pain intensitymeasured with the visual analog scale. The secondary outcomes will include the IBS Symptom Severity Scale, IBS Quality of Life questionnaire, pain threshold (PT), and the Symptom Checklist-90 for psychological distress. The PT will be measured before and after every treatment. All other outcomes will be evaluated before the 1st treatment, after 7th and 14th treatment, and 3 months later during follow-up.DiscussionThe aim of this study is to assess the analgesic effect of EA at homotopic (abdomen) acupoints and heterotopic (lower limb) acupoints on abdominal pain in patients with IBS, as well as the difference in analgesic effects between noxious and innocuous stimulation.Trial registrationChinese Clinical Trial Registry, ChiCTR-IPR-15006879. Registered on 5 August 2015.
基金：
National Natural Science Fund of ChinaNational Natural Science Foundation of China (NSFC) [8167151795]
第一作者机构：[1]The Secondary Medical College, Guangzhou University of Traditional Chinese Medicine, 111 Dade Road, Guangzhou 510120, People’s Republic of China.
通讯作者：
推荐引用方式(GB/T 7714)：
Peng Yanhui,You Hui,Chen Xiaoman,et al.Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial[J].TRIALS.2018,19:doi:10.1186/s13063-018-2948-1.
APA：
Peng, Yanhui,You, Hui,Chen, Xiaoman,Chen, Yanbing,Yang, Yiling...&Liu, Jianhua.(2018).Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial.TRIALS,19,
MLA：
Peng, Yanhui,et al."Effect of electroacupuncture at homotopic and heterotopic acupoints on abdominal pain in patients with irritable bowel syndrome: study protocol for a randomized controlled trial".TRIALS 19.(2018)
