Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N-(2-Furanylmethyl) Alkynamides under Air
机构：[1]Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China[2]Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, Laboratory of Insect Toxicology, South China Agricultural University, Guangzhou 510642, P. R. China[3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, P. R. China广东省中医院
A protocol for synthesis of chalcone derivatives with a 2-pyridone subunit from N-(2-furanylmethyl) alkynamides is reported. This synthesis involves Pd/Cu-catalyzed oxidative furan-yne cyclization at room temperature in air and may proceed via nucleopalladation of the alkyne to form a vinylpalladium intermediate, with a furan ring acting as the nucleophile.
基金：
National Program on Key Research Project [2016YFA0602900]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572068]; Science and Technology Program of Guangzhou, China [201707010057]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2017A030312005]; Science and Technology Planning Project of Guangdong Province, China [2017A020216021, 2014A020221035]
第一作者机构：[1]Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Yongjie,Fei ChengCheng,Wang Kai,et al.Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N-(2-Furanylmethyl) Alkynamides under Air[J].ORGANIC LETTERS.2018,20(8):2273-2277.doi:10.1021/acs.orglett.8b00618.
APA：
Yang, Yongjie,Fei, ChengCheng,Wang, Kai,Liu, Bo,Jiang, Dingxin&Yin, Biaolin.(2018).Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N-(2-Furanylmethyl) Alkynamides under Air.ORGANIC LETTERS,20,(8)
MLA：
Yang, Yongjie,et al."Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N-(2-Furanylmethyl) Alkynamides under Air".ORGANIC LETTERS 20..8(2018):2273-2277
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