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Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy.

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收录情况： ◇ SCIE

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机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. [2]Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China. [3]Guangzhou University of Chinese Medicine, Guangzhou, China. [4]School of Medicine, South China University of Technology, Guangzhou, China.

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are activated under pathological conditions, such as cancer, or mature myeloid cells that are converted immune-suppressive cells via tumor-derived exosomes, and potently support the tumor processes at different levels. Currently, multiple studies have demonstrated that MDSCs induce immune checkpoint blockade (ICB) therapy resistance through their contribution to the immunosuppressive network in the tumor microenvironment. In addition, non-immunosuppressive mechanisms of MDSCs such as promotion of angiogenesis and induction of cancer stem cells also exert a powerful role in tumor progression. Thus, MDSCs are potential therapeutic targets to enhance the antitumor efficacy of ICB therapy in cases of multiple cancers. This review focuses on the tumor-promoting mechanism of MDSCs and provides an overview of current strategies that target MDSCs with the objective of enhancing the antitumor efficacy of ICB therapy.Copyright © 2021 Li, Zhong, Deng, Guo, Lu, Lin, Huang and Wang.

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中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区

医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2019]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 5.085 出版当年[2019版] 5.733 出版当年五年平均 4.716 出版前一年[2018版] 7.561 出版后一年[2020版]

第一作者：

第一作者机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. [2]Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.

通讯作者：

通讯机构： [1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China. [2]Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.

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