机构：[1]Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.广东省中医院[2]Guangzhou University of Chinese Medicine, Guangzhou, China.[3]Shenzhen Bao’an Research Center for Acupuncture and Moxibustion, Guangdong Province, Shenzhen, China.[4]Sanming Project of Medicine in Shenzhen, Guangdong Province, Shenzhen, China.
Introduction: Poststroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes and quality of life. Antidepressants are the first-line treatment for PSD, but many reported side effects remain. Clinical research has shown that acupuncture has a positive effect on PSD. This trial aims to study the efficacy and safety of acupuncture for PSD and to explore its effect on cognitive function. It is hypothesized that acupuncture treatment improves depressive symptoms, cognitive behavior, and negative emotion processing bias in PSD. Methods: In this randomized, placebo-controlled, single-blinded trial, fifty-six people with PSD will be randomly allocated into the intervention (n=28) or control (n=28) groups. The intervention group will receive acupuncture treatment, and the control group will receive sham acupuncture treatment, in 20 sessions over 4 weeks. The primary outcome is the change from baseline in the Hamilton Depression Scale-17 (HAMD-17) scores at week 4. Secondary outcomes include the Wisconsin Card Sorting Test (WCST) and latency and amplitude of P1, N170, and P3 of the event related potentials (ERPs) components to assess the changes in cognitive function and electroencephalography. Outcomes are assessed at baseline and post intervention. Discussion: Acupuncture therapy could become an alternative treatment for PSD, and it is expected that this trial will provide reliable clinical evidence for the future use of acupuncture for the treatment of PSD.
基金：
National Natural Science
Foundation of China (Grant No.: 82004466), the Foundation for Basic and
Applied Basic Research of Guangdong Province (Grant No.:
2019A1515110366), Guangdong Province Academy of Chinese Medicine
(Grant No.: YN2019ML13), Key-Area Research and Development Program of
Guangdong Province (Grant No.: 2020B1111100007), Double First-class and
High-level University Discipline Collaborative Innovation Team Project of
Guangzhou University of traditional Chinese Medicine (Grant No.: 2021xk22),
and Guangdong Provincial Hospital of Chinese Medicine studio of Linnan
Acupuncture and Chinese Herbal (Grant No.: E43612).
第一作者机构：[1]Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.[2]Guangzhou University of Chinese Medicine, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构：[1]Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.[2]Guangzhou University of Chinese Medicine, Guangzhou, China.[3]Shenzhen Bao’an Research Center for Acupuncture and Moxibustion, Guangdong Province, Shenzhen, China.[4]Sanming Project of Medicine in Shenzhen, Guangdong Province, Shenzhen, China.
推荐引用方式(GB/T 7714)：
Chen Ling,Chen Yi,Wu Lihua,et al.Efficacy of acupuncture on cognitive function in poststroke depression: study protocol for a randomized, placebo-controlled trial[J].TRIALS.2022,23(1):doi:10.1186/s13063-022-06011-7.
APA：
Chen, Ling,Chen, Yi,Wu, Lihua,Fu, Wen,Wu, Luanmian&Fu, Wenbin.(2022).Efficacy of acupuncture on cognitive function in poststroke depression: study protocol for a randomized, placebo-controlled trial.TRIALS,23,(1)
MLA：
Chen, Ling,et al."Efficacy of acupuncture on cognitive function in poststroke depression: study protocol for a randomized, placebo-controlled trial".TRIALS 23..1(2022)
