机构：[1]Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China,[2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou, China,大德路总院检验科大德路总院检验科广东省中医院[3]Department of Translational Medicine Research Institute, Guangzhou Huayin Medical Laboratory CenterLtd., Guangzhou, China,[4]Department of Laboratory Medicine, Guangzhou Eighth People’s Hospital, Guangzhou MedicalUniversity, Guangzhou, China,[5]Emergency Department, The Second Affiliated Hospital of Guangzhou University of ChineseMedicine, Guangzhou, China,[6]Department of Laboratory Medicine, The Fourth People’s Hospital of Foshan, Foshan, China,[7]Department of Clinical Laboratory, The First People’s Hospital of Foshan, Foshan, China,[8]Department of InfectiousDiseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China,[9]Department ofPulmonary and Critical Care Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China,[10]TheThird Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences),Jinan, China,[11]Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional ChineseMedicine, Jinan, China
The prevention of the COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients and re-detectable positive cases remain unclear. Here we comprehensively analyzed the peripheral T-cell receptor (TCR) repertoire of 54 COVID-19 patients in different courses, including asymptomatic, symptomatic, convalescent, and re-detectable positive cases. We identified a set of V-J gene combinations characterizing the upward immune responses through asymptomatic and symptomatic courses. Furthermore, some of these V-J combinations could be awakened in the re-detectable positive cases, which may help predict the risk of recurrent infection. Therefore, TCR repertoire examination has the potential to strengthen the clinical surveillance and the immunotherapy development for COVID-19.
基金：
Science and Technology Innovation
Project of Foshan Municipality (2020001000431), National
Key Research and Development Project (2020YFA0708001),
and Guangdong Provincial Science and Technology
Project (2020A1414010363).
第一作者机构：[1]Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China,
共同第一作者：
通讯作者：
通讯机构：[10]TheThird Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences),Jinan, China,[11]Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional ChineseMedicine, Jinan, China
推荐引用方式(GB/T 7714)：
Li Yizhe,Hu Jian,Wang Yongsi,et al.T-Cell Repertoire Characteristics of Asymptomatic and Re-Detectable Positive COVID-19 Patients[J].FRONTIERS IN IMMUNOLOGY.2022,12:doi:10.3389/fimmu.2021.769442.
APA：
Li, Yizhe,Hu, Jian,Wang, Yongsi,Liu, Dongdong,Shi, Yaling...&Xu, Jianhua.(2022).T-Cell Repertoire Characteristics of Asymptomatic and Re-Detectable Positive COVID-19 Patients.FRONTIERS IN IMMUNOLOGY,12,
MLA：
Li, Yizhe,et al."T-Cell Repertoire Characteristics of Asymptomatic and Re-Detectable Positive COVID-19 Patients".FRONTIERS IN IMMUNOLOGY 12.(2022)
医学