详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Microbiology and Immunology. Institute of Geriatric Immunology. School of Medicine, Jinan University, Guangzhou, 510000, China.. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, 510000, China.. [3]Affiliated Huaqiao Hospital, Jinan University, Guangzhou, 510000, China.. [4]Department of Geriatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510000, China.. [5]Guangzhou Center for Disease Control and Prevention, Guangzhou, 510000, China.. [6]Meng Yi Center Limited, Macau, 999078, China.. [7]Biomedical Translational Research Institute, Jinan University, Guangzhou, 510000, China.. [8]ShangHai GuangHua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200052, China.. [9]Arthritis Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai University of Chinese Traditional Medicine, Shanghai, 200052, China.. [10]School of Medicine &amp. Institute of Laboratory Animal Sciences, Jinan University, Guangzhou, 510000, China.. [11]School of Medicine, Jinan University, Guangzhou, 510000, China.. [12]Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, 510000, China.

出处：

DOI：

摘要：

Here, we evaluated the immune properties of the HLA-A2 restricted CD8+ T cell epitopes containing mutations from B.1.1.7, and furthermore performed a comprehensive analysis of the SARS-CoV-2 specific CD8+ T cell responses from COVID-19 convalescent patients and SARS-CoV-2 vaccinees recognizing the ancestral Wuhan strain compared to B.1.1.7. First, most of the predicted CD8+ T cell epitopes showed proper binding with HLA-A2, while epitopes from B.1.1.7 had lower binding capability than those from the ancestral strain. In addition, these peptides could effectively induced the activation and cytotoxicity of CD8+ T cells. Our results further showed that at least two site mutations in B.1.1.7 resulted in a decrease in CD8+ T cell activation and a possible immune evasion, namely A1708D mutation in ORF1ab1707-1716 and I2230T mutation in ORF1ab2230-2238. Our current analysis provides information that contributes to the understanding of SARS-CoV-2-specific CD8+ T cell responses elicited by infection of mutated strains or vaccination.© 2022 The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2025]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

第一作者：

第一作者机构： [1]Department of Microbiology and Immunology. Institute of Geriatric Immunology. School of Medicine, Jinan University, Guangzhou, 510000, China.. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, 510000, China..

共同第一作者：

通讯作者：

通讯机构： [1]Department of Microbiology and Immunology. Institute of Geriatric Immunology. School of Medicine, Jinan University, Guangzhou, 510000, China.. [2]Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, 510000, China.. [3]Affiliated Huaqiao Hospital, Jinan University, Guangzhou, 510000, China.. [8]ShangHai GuangHua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200052, China.. [9]Arthritis Institute of Integrated Traditional Chinese and Western Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai University of Chinese Traditional Medicine, Shanghai, 200052, China..

推荐引用方式(GB/T 7714)：

APA：

MLA：