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Combination therapy with artemether and enalapril improves type 1 diabetic nephropathy through enhancing antioxidant defense.

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Yijun Chen[1] * ; Wenci Weng[1] * ; Haiyang Zhang[4] ; Guangli Rong[1] ; Xuewen Yu[2] ; Qing Wei[3] ; Mumin Shao[2] ; Yuchun Cai[1] ; Pengxun Han[1,*1] ; Huili Sun[1,4,*1] ;
机构： [1]Departments of Nephrology,Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China [2]Departments of Pathology,Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China [3]Departments of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China [4]Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Shenzhen 518000, Guangdong, China
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关键词： Diabetic nephropathy artemether enalapril ACEi combination

摘要：
Previous studies have demonstrated that both artemether and enalapril are effective in treating diabetic nephropathy (DN). However, the effects and underlying mechanisms of their combination in treating DN remain unknown. The experimental DN model was induced by injecting streptozotocin (STZ) into male C57BL/6J mice. Mice were randomly allocated to the Type 1 diabetes control (T1D-ctrl), STZ, STZ + artemether (STZ + Art), STZ + enalapril (STZ + ACEi), or STZ + artemether + enalapril (STZ + Art + ACEi) group. The interventions lasted for 8 weeks. At the end of the experiment, related urine and serum biochemical values, such as urinary albumin excretion (UAE) and fasting blood glucose (FBG), were measured. In addition, blood pressure (BP) and kidney morphologic changes were also evaluated. The expression of oxidative stress related molecules, such as catalase, acetylated SOD2 (k68) and acetylated SOD2 (k122) in the kidney were measured. Results: combination therapy showed more pronounced effects in reducing UAE, FBG, and BP than any single drug. Typical diabetic kidney injuries, such as heavier kidney weight, and glomerular and tubular hypertrophy, were also further alleviated by combination therapy. Combination therapy also up-regulated the expression of catalase and down-regulated the expression of acetylated SOD2 (k68) and acetylated SOD2 (k122). Combination therapy with artemether and enalapril exhibited renoprotective effects in STZ-induced T1D mice superior to a single drug. The mechanism might be associated with their synergistic effects in enhancing antioxidant defense.AJTR Copyright © 2022.

基金：
National Natural Science Foundation of China (82004156, 81673794), Shenzhen Science and Technology Project (JCYJ201908121836- 03627), Shenzhen Fund for Guangdong Provincial High level Clinical Key Specialties.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学 4 区 医学：研究与实验
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 肿瘤学
JCR分区：
出版当年[2020]版：
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q3 ONCOLOGY
最新[2023]版：
Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Departments of Nephrology,Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Departments of Nephrology,Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China [4]Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Shenzhen 518000, Guangdong, China [*1]Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, 1 Fuhua Road, Futian District, Shenzhen 518033, Guangdong, China.
推荐引用方式(GB/T 7714)：
Yijun Chen,Wenci Weng,Haiyang Zhang,et al.Combination therapy with artemether and enalapril improves type 1 diabetic nephropathy through enhancing antioxidant defense.[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2022,14(1):211-222.
APA：
Yijun Chen,Wenci Weng,Haiyang Zhang,Guangli Rong,Xuewen Yu...&Huili Sun.(2022).Combination therapy with artemether and enalapril improves type 1 diabetic nephropathy through enhancing antioxidant defense..AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,14,(1)
MLA：
Yijun Chen,et al."Combination therapy with artemether and enalapril improves type 1 diabetic nephropathy through enhancing antioxidant defense.".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 14..1(2022):211-222

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