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LncRNA BC200/miR-150-5p/MYB positive feedback loop promotes the malignant proliferation of myelodysplastic syndrome.

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机构： [1]Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033 Guangdong, China [2]The First Affiliated Hospital, Department ofClinical Laboratory, Hengyang Medical School, University of South China, Hengyang 421001 Hunan, China [3]Molecular Biology Research Center & Center for MedicalGenetics, School of Life Sciences, Central South University, Changsha 410078 Hunan, China [4]Department of Hematology, Xiangya Hospital, Central South University,Changsha 410008, China [5]The First Affiliated Hospital, Department of Hematology, Hengyang Medical School, University of South China, Hengyang 421001 Hunan, China [6]Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410078 Hunan, China

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Myelodysplastic syndrome (MDS) is a group of heterogeneous hematologic malignancies with a risk of transformation to acute myeloid leukemia. Understanding the molecular mechanisms of the specific roles of long noncoding RNAs (lncRNAs) in MDS would create novel ways to identify diagnostic and therapeutic targets. The lncRNA BC200 is upregulated and acts as an oncogene in various cancers; however, its expression, clinical significance, and roles in MDS remain unclear. Here, we found that BC200 was highly expressed in MDS patients compared with normal individuals. Knockdown of BC200 inhibited MDS cell proliferation, colony formation, and cell cycle progression in vitro and suppressed the growth and invasiveness of MDS cells in vivo. Mechanistic investigations revealed that BC200 functioned as a miRNA sponge to positively regulate the expression of MYB through sponging miR-150-5p and subsequently promoted malignant proliferation of MDS cells. Conversely, we found that BC200 was a direct transcriptional target of MYB, and knockdown of MYB abolished the oncogenic effect of BC200/miR-150-5p. Taken together, our results revealed that the BC200/miR-150-5p/MYB positive feedback loop promoted the proliferation of MDS cells and is expected to be a potential biomarker and therapeutic target in MDS.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 2 区细胞生物学

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出版当年[2020]版：

Q1 CELL BIOLOGY

最新[2024]版：

Q1 CELL BIOLOGY

影响因子： 9.6 最新[2024版] 9.8 最新五年平均 8.469 出版当年[2020版] 8.713 出版当年五年平均 6.304 出版前一年[2019版] 9.696 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033 Guangdong, China [2]The First Affiliated Hospital, Department ofClinical Laboratory, Hengyang Medical School, University of South China, Hengyang 421001 Hunan, China

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通讯作者：

通讯机构： [1]Department of Clinical Laboratory, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033 Guangdong, China [2]The First Affiliated Hospital, Department ofClinical Laboratory, Hengyang Medical School, University of South China, Hengyang 421001 Hunan, China [3]Molecular Biology Research Center & Center for MedicalGenetics, School of Life Sciences, Central South University, Changsha 410078 Hunan, China [6]Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha 410078 Hunan, China

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