Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats.
机构：[1]Department of Traditional Chinese Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[2]College of Traditional Chinese medicine, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[3]The First Affiliated hospital of Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[4]Guangdong Provincial Key laboratory of Traditional Chinese Informatization, 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, P. R. China[5]Cancer research Institution, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China
Glycine is commonly used as an additive in bone health supplements. In addition, the activity and differentiation of bone mesenchymal stem cells (BMSCs) are essential to bone metabolism but the effect of glycine on bone metabolism and its specific mechanism have not been fully clarified. In this study, we constructed an ovariectomized (OVX) rat model to evaluate the effects of glycine on bone quality estrogen receptor alpha (ERα)-deficient BMSCs to explore how glycine mediated ERα regulation of the osteogenic and adipogenic differentiation of BMSCs. Finally, autodock analysis was used to assess the affinity of glycine for ERα. The results showed that glycine significantly moderated bone mass and bone microstructure in OVX rats and stimulated osteogenic differentiation and attenuated adipogenic differentiation in OVX rats and BMSCs, and that these effects could be abolished by ICI182780. Further docking experiments showed that glycine and ERα have a stronger affinity, and finally proved that the impact of glycine could be blocked by ERα. Therefore, we concluded that glycine stimulated osteogenesis and attenuated adipogenesis in OVX rats, a process which may involve the ERα-mediated ER signaling pathway. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
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外文
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出版当年[2021]版：
大类|2 区农林科学
小类|2 区食品科技
最新[2025]版：
大类|3 区医学
小类|2 区食品科技
第一作者：
第一作者机构：[1]Department of Traditional Chinese Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[4]Guangdong Provincial Key laboratory of Traditional Chinese Informatization, 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, P. R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Traditional Chinese Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[3]The First Affiliated hospital of Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China[4]Guangdong Provincial Key laboratory of Traditional Chinese Informatization, 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, P. R. China[5]Cancer research Institution, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, P. R. China
推荐引用方式(GB/T 7714)：
Li Xiaoyun,Lin Qing,Cui Yan,et al.Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats.[J].Molecular nutrition & food research.2022,e2100857.doi:10.1002/mnfr.202100857.
APA：
Li Xiaoyun,Lin Qing,Cui Yan,Wang Haoyu,Wang Panpan...&Zhu Xiaofeng.(2022).Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats..Molecular nutrition & food research,,
MLA：
Li Xiaoyun,et al."Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats.".Molecular nutrition & food research .(2022):e2100857
