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PIWI-Interacting RNA Pathway Genes: Potential Biomarkers for Clear Cell Renal Cell Carcinoma.

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机构： [1]Yingde Center, Institute of Kidney Surgery, Jinan University, Guangdong, China [2]Postdoctoral Mobile Station, The First Clinical Medical College of Jinan University, Guangzhou, China [3]Department of Urology, People’s Hospital of Yingde City, Yingde, China [4]Department of Urology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China [5]Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road, Guangzhou, China [6]College of Pharmacy, Jinan University, Guangzhou 510632, China [7]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China

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Clear cell renal cell carcinoma (ccRCC) is one of the most lethal malignancies in the urinary system, yet effective diagnostic and prognostic markers are lacking. Recently, several of piRNA pathway genes have been reported to be associated with cancer diagnosis and prognosis, but their role in ccRCC is still unclear.We analysed the expression of 27 piRNA pathway genes in 539 kidney renal clear cell carcinoma (KIRC) and 72 nontumor tissue samples (data from TCGA), and 12 mRNAs were significantly different. The aim was to sift the piRNA pathway genes that are correlated with ccRCC patient survival and to construct a piRNA pathway gene risk prognostic model using Kaplan-Meier survival curve and ROC curve, respectively.5 piRNA pathway genes (TDRD7, GPAT2, PLD6, SUV39H1, and DOM3Z) were picked out and used to construct the piRNA pathway gene risk model. Kaplan-Meier survival curve analysis showed that compared with that of the low-risk group of ccRCC patients, the OS of the high-risk group of ccRCC patients was significantly reduced. The predictive performance of the prognostic risk model was measured using a ROC curve, which individually showed AUC values for 1 year of 0.707, for 3 years of 0.713, and for 5 years of 0.701. Moreover, the mRNA and protein expression levels of TDRD7 were overexpressed in the ccRCC datasets (data from our cohort, TCGA, GEO, and CPTAC) and ccRCC cell lines, and the expression levels correlated with the clinicopathological characteristics in ccRCC. The Tumor Immune Estimation Resource (TIMER) showed that the mRNA expression level of TDRD7 was positively related to tumor immune infiltrating cells (TICs) in ccRCC. Mechanistically, gene set enrichment analysis (GSEA) was performed to uncover the mechanism of TDRD7 in ccRCC. In summary, the piRNA pathway genes,especially TDRD7, may be potential cancer diagnostic and prognostic biomarkers of ccRCC.Copyright © 2022 Baoli Heng et al.

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大类 | 4 区医学

小类 | 4 区生物工程与应用微生物 4 区遗传学 4 区医学：研究与实验 4 区病理学

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第一作者机构： [1]Yingde Center, Institute of Kidney Surgery, Jinan University, Guangdong, China [2]Postdoctoral Mobile Station, The First Clinical Medical College of Jinan University, Guangzhou, China [3]Department of Urology, People’s Hospital of Yingde City, Yingde, China

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通讯机构： [1]Yingde Center, Institute of Kidney Surgery, Jinan University, Guangdong, China [3]Department of Urology, People’s Hospital of Yingde City, Yingde, China [6]College of Pharmacy, Jinan University, Guangzhou 510632, China [7]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China

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