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Propionic acid regulates immune tolerant properties in B Cells.

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机构： [1]Department of Ultrasonic, The Second Xiangya Hospital of Central South University, Changsha, China [2]Research Center of Ultrasonography, The Second Xiangya Hospital of Central South University, Changsha, China [3]Department of Gastroenterology, Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou, China [4]Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital, Hunan University of Chinese Medicine, Changsha, China [5]Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, China [6]Department of Life Science, McMaster University, Hamilton, Ontario, Canada [7]Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China [8]State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China

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Interleukin 10 (IL-10)-producing B cells (B10 cells) are a canonical cell fraction for regulating other activities of immune cells. Posttranscriptional modification of IL-10 in B10 cells is not yet fully understood. Short-chain fatty acids play an important role to regulate the functions of immune cells. This study aims to clarify the role of propionic acid (PA), a short-chain fatty acid, in regulating the expression of IL-10 in B10 cells. Blood samples were collected from patients with food allergy (FA) and healthy subjects. Serum and cellular components were prepared with the samples, and analysed by enzyme-linked immunosorbent assay and flow cytometry, respectively. The results showed that serum PA levels were lower in FA patients. PA concentrations were negatively correlated with serum cytokine Th2 concentrations, specific IgE concentrations in serum and skin prick test results. The peripheral frequency of B10 cells and the production of IL-10 in B cells were also associated with serum PA concentrations. Activation of B cells by CpG induced the production of IL-10 and tristetretrprolin (TTP), in which TTP caused the spontaneous decay of IL-10 mRNA. PA was necessary to stabilize the IL-10 mRNA in B cells by inducing the production of granzyme B, which resulted in the degradation of the IL-10 mRNA. Administration of PA attenuated FA response in mice by maintaining homeostasis of B10 cells. In conclusion, PA is needed to stabilize the expression of IL-10 in B10 cells. PA administration can mitigate experimental FA by maintaining B10 cell functions.© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Ultrasonic, The Second Xiangya Hospital of Central South University, Changsha, China [2]Research Center of Ultrasonography, The Second Xiangya Hospital of Central South University, Changsha, China

通讯作者：

通讯机构： [4]Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital, Hunan University of Chinese Medicine, Changsha, China [7]Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China [8]State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China [*1]Shenzhen University School of Medicine, Room A7-509, Lihu Campus, 1066 Xueyuan Blvd, Shenzhen 518055, China. [*2]Department of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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