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IL-17A in diabetic kidney disease: protection or damage.

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机构： [1]Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China [2]Pi-Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China [3]Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510006, PR China

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The effect of IL-17A in diabetic kidney disease (DKD) has received increasing attention. Interleukin (IL)-17A promotes renal inflammation and the progression of DKD, and IL-17A deficiency improves experimental DKD. However, recent studies have found that the effect of IL-17A on DKD is more complicated than the negative impact. IL-17A alleviates renal inflammation and fibrosis via regulating autophagy or the macrophage phenotype. Moreover, paradoxical expression of IL-17A has been reported in human DKD. This review focuses on how IL-17A affects the progression of DKD and the resulting opportunities and challenges.Copyright © 2022 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

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第一作者机构： [1]Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China

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