机构：[1]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China.[2]Department of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.[3]School of Life Sciences and Li Dak Sum Yip Yio Chin R & D Centre for Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P.R. China.
Resina Draconis (RD), also known as 'dragon's blood', contains a broad range of natural compounds, such as flavonoids, stilbenes and dihydrochalcones. It is clinically used to enhance blood circulation. However, the major components of RD suffer from relatively poor water solubility. Glycosylation is a critical determinant for modulating solubility and improving bioavailability and bioactivity of natural products. Herein, we report a novel method to efficiently synthesize glycosidic derivatives of the major polyphenols in RD using a microbial glycosyltransferase, i.e., YjiC1. Solubility test showed that the synthetic glycosidic derivatives displayed higher water solubility than the raw materials. This research sheds light on the structural modification of natural products for higher water solubility, which is important for innovative drug discovery.
基金：
the National Natural Science Foundation of China (No: 81872760
and 81860797), Natural Science Foundation of Guangdong province (2021A1515011251) and
Guangdong scientific scheme (2021A0505030032).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区化学
小类|3 区应用化学3 区药物化学
最新[2025]版：
大类|3 区化学
小类|3 区应用化学4 区药物化学
第一作者：
第一作者机构：[1]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Chen,Tang Ding,Xu Wei,et al.Glycosylation of the polyphenols from Resina draconis by glycosyltransferase YjiC1.[J].Natural product research.2022,1-8.doi:10.1080/14786419.2022.2066100.
APA：
Wang Chen,Tang Ding,Xu Wei,Liu Yan,Huang Zhao-He...&Jiang Ren-Wang.(2022).Glycosylation of the polyphenols from Resina draconis by glycosyltransferase YjiC1..Natural product research,,
MLA：
Wang Chen,et al."Glycosylation of the polyphenols from Resina draconis by glycosyltransferase YjiC1.".Natural product research .(2022):1-8
