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The role of m6A methylation in osteosarcoma biological processes and its potential clinical value.

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机构： [1]Shunde Hospital, Southern Medical University (The First People’s Hospitalof Shunde), Foshan, China [2]Guangdong Provincial Key Laboratory of MedicalBiomechanics, School of Basic Medical Sciences, Southern Medical University,Guangzhou, China [3]Guangdong Engineering Research Center for Translationof Medical 3D Printing Application, Southern Medical University, Guangzhou,China [4]Guangdong Innovation Platform for Translation of 3D PrintingApplication, Southern Medical University, Guangzhou, China [5]Departmentof Orthopaedics, Affiliated Traditional Chinese Medicine Hospital, SouthwestMedical University, Luzhou, China [6]The Precision Medicine Institute, The ThirdAffiliated Hospital, Southern Medical University, Guangzhou, China [7]Departmentof Anatomy, Hebei Medical University, Shijiazhuang, China

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Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults and has a poor prognosis. Recent developments in the field of high-throughput sequencing technology, particularly in methylated RNA immunoprecipitation sequencing (MeRIP-seq), have led to renewed interest in RNA methylation. Among the various RNA modifications, N6-methyladenosine (m6A) modifications are the most common. Emerging evidence suggests that m6A methylation can affect the complexity of cancer progression by regulating biological functions related to cancer. In this review, we will shed light on recent findings regarding the biological function of m6A methylation in OS and discuss future research directions and potential clinical applications of RNA methyltransferases in OS.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区遗传学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区遗传学

第一作者：

第一作者机构： [1]Shunde Hospital, Southern Medical University (The First People’s Hospitalof Shunde), Foshan, China [2]Guangdong Provincial Key Laboratory of MedicalBiomechanics, School of Basic Medical Sciences, Southern Medical University,Guangzhou, China

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通讯机构： [1]Shunde Hospital, Southern Medical University (The First People’s Hospitalof Shunde), Foshan, China [2]Guangdong Provincial Key Laboratory of MedicalBiomechanics, School of Basic Medical Sciences, Southern Medical University,Guangzhou, China [3]Guangdong Engineering Research Center for Translationof Medical 3D Printing Application, Southern Medical University, Guangzhou,China [4]Guangdong Innovation Platform for Translation of 3D PrintingApplication, Southern Medical University, Guangzhou, China

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