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Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress.

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资源类型：
Pubmed体系：
作者：
Yu Tian[1,2] * ; Ye Xianying[1,2] * ; Deng Fang[4] * ; Song Zhuoyue[1,2,3] ; Zhu Mengru[1,2] ; Chen Yao[1,2] ; Liu Tao[1,2] ; Liu Shihui[1,2,*1] ; Li Shijie[1,2,*1] ;
机构： [1]Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [3]School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong 999077, PR China [4]First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
出处：
DOI： 10.1016/j.ijbiomac.2022.04.053
ISSN：

摘要：
The objective of this study was to investigate the effect of polysaccharides from Ostrea rivularis (ORP) relieving reproductive damage by regulating autophagy. The results showed that ORP intervention could alleviate the pathological changes of the testis and alleviate oxidative stress which were caused by cyclophosphamide (CTX) in vivo, including improve sperm symptoms and rise testosterone level. Reduced level of autophagy after ORP intervention was observed by transmission electron microscopy (TEM), which implied that ORP might regulate cell autophagy. In vitro experiments showed that ORP could alleviate the damage of TM4 cells induced by H2O2, reduce the level of intracellular ROS and the content of MDA. Autophagy-related protein expressions of p62, LC3, Beclin-1 before and after 3-MA inhibitor intervention were also proved that ORP could regulate autophagy. Overall, these results confirmed that ORP could reduce reproductive damage related to autophagy.Copyright © 2021. Published by Elsevier B.V.

基金：
This work was supported by the National Natural Science Foundation of China (No. 81803865). National Key R&D Program of China (No. 2019YFC1709100; 2019YFC1709102). Discipline Collaborative Innovation Team Program of Double First-class and High-level Universities for Guangzhou University of Chinese Medicine (No. 2021XK01).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 高分子科学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [1]Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]South China Research Center for Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [*1]Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China.
推荐引用方式(GB/T 7714)：
Yu Tian,Ye Xianying,Deng Fang,et al.Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress.[J].International journal of biological macromolecules.2022,209(Pt A):655-667.doi:10.1016/j.ijbiomac.2022.04.053.
APA：
Yu Tian,Ye Xianying,Deng Fang,Song Zhuoyue,Zhu Mengru...&Li Shijie.(2022).Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress..International journal of biological macromolecules,209,(Pt A)
MLA：
Yu Tian,et al."Protective effect of polysaccharides from Ostrea rivularis against reproductive injury via regulating autophagy induced by oxidative stress.".International journal of biological macromolecules 209..Pt A(2022):655-667

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