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DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p.

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资源类型：
Pubmed体系：
作者：
Li Chunmei[1,2] * ; Li Xiaoqiong[1,2] ; Zhang Yi[2,3] ; Wu Liangzhi[1,2] ; He Jingjun[1,2] ; Jiang Nan[2,3] ; Zhao Hui[2,3] ; Liu Wenwen[2,3] ;
机构： [1]International Medical Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China [2]Department of Traditional Chinese Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China [3]Department of Gynecology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
出处：
DOI： 10.1007/s11356-022-19962-w
ISSN：

摘要：
Deregulated lncRNA DSCAM-AS1 expression was found in several tumors. However, mechanism and functional role of DSCAM-AS1 in cervical carcinoma remain unknown. DSCAM-AS1 was detected in cervical carcinoma specimens and cells by RT-qPCR. CCK-8, Matrigel transwell, and flow cytometry were conducted to determine cell functions. In this research, we firstly we explored DSCAM-AS1 expression in cervical carcinoma cells and specimens. We revealed that DSCAM-AS1 was upregulated in cervical carcinoma lines (C4-1, Caski, Hela, and Siha) compared to GH329 cells. DSCAM-AS1 was upregulated in cervical carcinoma specimens compared to control no-tumor specimens. Overexpression of DSCAM-AS1 induced cervical carcinoma cell growth and cycle. Moreover, our data revealed that miR-338-3p expression was downregulated in cervical carcinoma cells and specimens. There was a negative correlation between miR-338-3p expression and DSCAM-AS1 expression in cervical carcinoma specimens. Elevated expression of miR-338-3p decreased cervical carcinoma cell growth and cycle and invasion. Furthermore, luciferase reporter analysis revealed that miR-338-3p overexpression suppressed luciferase activity of WT-DSCAM-AS1 vector but not the mut-DSCAM-AS1. Ectopic expression of DSCAM-AS1 decreased miR-338-3p expression in the Siha cell. Overexpression of DSCAM-AS1 promoted cervical carcinoma cell growth and cycle via regulating miR-338-3p. These results suggested that DSCAM-AS1 functions as one oncogene through sponging miR-338-3p in cervical carcinoma.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 环境科学与生态学
小类 | 3 区 环境科学
最新[2025]版：
无
第一作者：
第一作者机构： [1]International Medical Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China [2]Department of Traditional Chinese Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
通讯作者：
通讯机构： [1]International Medical Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China [2]Department of Traditional Chinese Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
推荐引用方式(GB/T 7714)：
Li Chunmei,Li Xiaoqiong,Zhang Yi,et al.DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p.[J].Environmental science and pollution research international.2022,doi:10.1007/s11356-022-19962-w.
APA：
Li Chunmei,Li Xiaoqiong,Zhang Yi,Wu Liangzhi,He Jingjun...&Liu Wenwen.(2022).DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p..Environmental science and pollution research international,,
MLA：
Li Chunmei,et al."DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p.".Environmental science and pollution research international .(2022)

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