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MiR-9-5p Inhibits the MMP+-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease.

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机构： [1]Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. [2]Department of Neurosurgery, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi, China. [3]Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. [4]Department of Neurosurgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi 332005, China. [5]Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

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The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson's disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson's disease.Copyright © 2022 Zhenyong Xiao et al.

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出版当年[2021]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

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出版当年[2020]版：

Q2 CELL BIOLOGY

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影响因子： 0 最新[2023版] 0 最新五年平均 6.543 出版当年[2020版] 7.454 出版当年五年平均 5.076 出版前一年[2019版] 7.31 出版后一年[2021版]

第一作者：

第一作者机构： [1]Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. [2]Department of Neurosurgery, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi, China.

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通讯作者：

通讯机构： [1]Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. [5]Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

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