As a critical member of the ubiquitin-specific proteolytic enzyme family, ubiquitin-specific peptidase 20 (USP20) regulates the stability of proteins via multiple signaling pathways. In addition, USP20 upregulation is associated with various cellular biological processes, such as cell cycle progression, proliferation, migration, and invasion. Emerging studies have revealed the pivotal role of USP20 in the tumorigenesis of various cancer types, such as breast cancer, colon cancer, lung cancer, gastric cancer and adult T cell leukemia. In our review, we highlight the different mechanisms of USP20 in various tumor types and demonstrate that USP20 regulates the stability of multiple proteins. Therefore, regulating the activity of USP20 is a novel tumor treatment. However, the clinical significance of USP20 in cancer treatment merits more evidence. Finally, different prospects exist for the continued research focus of USP20.
基金：
National Natural Science Foundation of China [81874173, 81472346]; Natural Science Foundation of Zhejiang Province [LY20H160033,2017205840, 2018274816, LGJ18H160001]
第一作者机构：[1]Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Med Oncol, Hangzhou 310003, Zhejiang, Peoples R China[2]Zhejiang Univ, Sch Med, Affiliated Hosp 1,Dept Med Oncol, Key Lab Canc Prevent & Intervent,Minist Educ, Hangzhou, Zhejiang, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Med Oncol, Hangzhou 310003, Zhejiang, Peoples R China[2]Zhejiang Univ, Sch Med, Affiliated Hosp 1,Dept Med Oncol, Key Lab Canc Prevent & Intervent,Minist Educ, Hangzhou, Zhejiang, Peoples R China
推荐引用方式(GB/T 7714)：
Li Qiong,Ye Chanqi,Tian Tian,et al.The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics[J].CELL DEATH & DISEASE.2022,13(5):doi:10.1038/s41419-022-04853-2.
APA：
Li, Qiong,Ye, Chanqi,Tian, Tian,Jiang, Qi,Zhao, Peng...&Ruan, Jian.(2022).The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics.CELL DEATH & DISEASE,13,(5)
MLA：
Li, Qiong,et al."The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics".CELL DEATH & DISEASE 13..5(2022)
生物学