机构：[1]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[2]Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China[3]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China[4]Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China深圳市中医院深圳医学信息中心
Bladder cancer(BC)is one of the most common urinary system tumors, which characterized by a high incidence. Polyporus polysaccharide is the main active component of polyporus, which is clinically used in the treatment of bladder cancer, but the mechanism is not clear. In previous study, we isolated homogeneous polyporus polysaccharide(HPP) with high purity from polyporus. The goal of this study was to assess the polarization of macrophages induced by HPP in the bladder tumor microenvironment and explored its anti-bladder cancer mechanism through BBN bladder cancer rat model and Tumor associated macrophages(TAM). The results suggested that HPP regulates TAM polarization to improve the tumor inflammatory microenvironment, possibly through the NF-kappa B/NLRP3 signaling pathway. Our results suggested that HPP may be a potential therapeutic agent for bladder tumors.
基金：
National Natural Science Foundation of China [81573769]; Special project of Guangdong Academy of Traditional Chinese Medicine [YN2019MJ02]; Project of Guangzhou University of Chinese Medicine [2021 XK72]
第一作者机构：[1]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[2]Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China[3]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Chunping,He Dongyue,Zhang Shihui,et al.Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-κB/NLRP3 Signaling[J].FRONTIERS IN IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.839460.
APA：
Liu, Chunping,He, Dongyue,Zhang, Shihui,Chen, Huiqi,Zhao, Jie...&Zeng, Xing.(2022).Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-κB/NLRP3 Signaling.FRONTIERS IN IMMUNOLOGY,13,
MLA：
Liu, Chunping,et al."Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-κB/NLRP3 Signaling".FRONTIERS IN IMMUNOLOGY 13.(2022)
医学