机构：[1]School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou 510006, China.[2]Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.[3]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.[4]The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.中山大学附属第一医院[5]School of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, China.[6]Pazhou Lab, Guangzhou 510335, China.
Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle interface. In this study, we demonstrated a methodology of determination of transdermal rate of metallic microneedle array through impedance measurements-based numerical check screening algorithm. Metallic sheet microneedle array sensors with different sizes were fabricated to evaluate different transdermal rates. In vitro sensing of hydrogen peroxide confirmed the effect of transdermal rate on the sensing outcomes. An FEM simulation model of a microneedle array revealed the monotonous relation between the transdermal state and test current. Accordingly, two methods were primely derived to calculate the transdermal rate from the test current. First, an exact logic method provided the number of unpenetrated tips per sheet, but it required more rigorous testing results. Second, a fuzzy logic method provided an approximate transdermal rate on adjacent areas, being more applicable and robust to errors. Real-time transdermal rate estimation may be essential for improving the performance of microneedle systems, and this study provides various fundaments toward that goal.
基金：
This work is supported in part by the National Natural Science Foundation of China
(Grant No. 32171456, 32171399, 61901535, 32171335, 31900954), The authors would like to acknowledge
financial support from National Key R&D Program of China (Grant No. 2021YFF1200700,
2021YFA0911100), Science and Technology Program of Guangzhou, China (Grant No. 202102080192,
202103000076), Guangzhou Science and technology planning project ( Grant No. 202103000010)
Guangdong Basic and Applied Basic Research Foundation (Grant No. 2019A1515012087,
2021A1515012261), and Pazhou Lab, Guangzhou (P2L2021KF0003).
第一作者机构：[1]School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou 510006, China.
通讯作者：
通讯机构：[1]School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou 510006, China.[4]The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
推荐引用方式(GB/T 7714)：
Mo Jingshan,Liu Junqing,Huang Shuang,et al.Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm.[J].MICROMACHINES.2022,13(5):doi:10.3390/mi13050718.
APA：
Mo Jingshan,Liu Junqing,Huang Shuang,Liang Baoming,Huang Xinshuo...&Chen Hui-Jiuan.(2022).Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm..MICROMACHINES,13,(5)
MLA：
Mo Jingshan,et al."Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm.".MICROMACHINES 13..5(2022)
