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A Study to Confirm the Accuracy of Locally Advanced Gastric Cancer Diagnosis

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多中心研究：

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研究单位： [1]Peking University [2]RenJi Hospital [3]Ruijin Hospital [4]West China Hospital [5]Beijing 302 Hospital [6]Fudan University [7]Peking University International Hospital [8]Guangdong Provincial Hospital of Traditional Chinese Medicine [9]Fujian Medical University Union Hospital [10]First Affiliated Hospital Xi'an Jiaotong University [11]Chinese PLA General Hospital [12]First Affiliated Hospital of Xinjiang Medical University [13]Tianjin Medical University General Hospital [14]The Second Affiliated Hospital of Dalian Medical University [15]Wuhan Union Hospital, China [16]Peking University People's Hospital [17]Weifang People's Hospital [18]Second Hospital of Jilin University [19]Fujian Province Tumor Hospital [20]Shanxi Province Cancer Hospital [21]The First Affiliated Hospital of Nanchang University [22]Tianjin Medical University Cancer Institute and Hospital [23]Shanghai Zhongshan Hospital [24]First Affiliated Hospital, Sun Yat-Sen University [25]The Affiliated Hospital of Qingdao University [26]The First Affiliated Hospital of Xiamen University [27]Beijing Hospital [28]Beijing Friendship Hospital [29]Qingdao Municipal Hospital [30]Guangdong Provincial People's Hospital [31]Affiliated Hospital of Qinghai University [32]Shandong Provincial Hospital [33]The First Hospital of Jilin University [34]Nanfang Hospital of Southern Medical University [35]Zhongshan Hospital Xiamen University [36]Hebei Medical University Fourth Hospital

关键词： Gastric cancer Clinical TNM staging Adenocarcinoma

研究目的：

With the introducing of neoadjuvant therapy, it becomes ever more important to evaluate the preoperative TNM (cTNM) stage accurately facilitating preoperative treatment as well as the adjuvant therapy. At present, the recommendation of neoadjuvant chemotherapy varies among guidelines especially between eastern and western countries. According to the updated Japanese gastric cancer treatment guidelines (ver.5), neoadjuvant chemotherapy is the recommended standard procedure for patients with cT2-4 stages. However, the acknowledgement of preoperative therapy accompanied by the higher risk of overtreatment. As mentioned in JCOG1302-A, the overall precision rate in cT staging is 38.8%. Patients diagnosed with pI stages postoperatively account for 6.5% in cT3-4N+ treatment indicating more likely to avoiding the overtreatment comparing to patients with other cT stages. Inspired by JCOG1302-A, this multicentre study prospectively collect data in preoperative TNM staging assessment using CT(computed tomography, CT) scan and the postoperative TNM (pTNM) staging according to histopathologically examination. By analyzing the accordance between the cTNM and pTNM, this study aims to evaluate the current accuracy of the cTNM staging in china, verifying the proportion of pI stages less than 5% in cIII stage diagnosis patients, learning the overtreating rate in neoadjuvant chemotherapy in China and furthermore, to discover the scope of beneficiaries for neoadjuvant chemotherapy.