研究单位：[1]Nanfang Hospital of Southern Medical University[2]Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University[3]Fifth Affiliated Hospital, Sun Yat-Sen University[4]Zhujiang Hospital[5]The First Affiliated Hospital of Guangzhou Medical University[6]Guangdong Provincial Hospital of Traditional Chinese Medicine[7]Guangzhou First People's Hospital[8]Fujian Provincial Hospital[9]The Affiliated Ganzhou Hospital of Nanchang University
Background: Continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) are two important PD modalities. To date, only three small sample randomized control trials(RCTs) comparing CAPD and APD have been conducted but yield inconsistent results. Objective: Investigators plan to initiate a multicenter, prospective, randomized cross-over study to compare the quality of life and dialysis adequacy in non-diabetic PD patients. Hypothesis: Patients' quality of life and dialysis adequacy on APD is no worse than on CAPD. Methods: This study plans to recruit 268 non-diabetic patients on maintenance peritoneal dialysis. Patients will randomly be assigned into groups A and B in a 1:1 ratio: group A receives APD from week 1 to 12 and changes to CAPD from week 13 to 24; group B receives CAPD from week 1 to 12 and changes to APD from week 13 to 24. Outcomes were evaluated at week 12 and week 24.
