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Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy

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研究单位： [1]Department of Neurology, Nanfang Hospital,Southern Medical University [2]The Fourth Affiliated Hospital of Guangzhou Medical University [3]The Affiliated Hospital of Inner Mongolia Medical University [4]Second Affiliated Hospital of Wenzhou Medical University [5]Second Affiliated Hospital of Guangxi Medical University [6]Fujian Medical University Union Hospital [7]Huizhou Municipal Central Hospital [8]Haikou People's Hospital [9]Kashgar 1st People's Hospital [10]Ganzhou City People's Hospital [11]Guangdong Provincial Hospital of Traditional Chinese Medicine [12]Huadu District People's Hospital of Guangzhou [13]Dongguan donghua hospital [14]Sinopharm North Hospital [15]Heyuan people's Hospital [16]Hainan People's Hospital [17]Hainan Traditional Chinese Medicine Hospital [18]The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine [19]The Second Hospital University of South China [20]Dongguan People's Hospital [21]Yueyang People's Hospital

关键词： Acute Ischemic Stroke Stress Ulcer Bleeding Mechanical Thrombectomy

研究目的：

Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel occlusive cerebral infarction, but 20-50% of patients still experience ineffective revascularization. Therefore, postoperative monitoring and treatment of patients with large vessel occlusions is crucial for early recognition, management and prevention of complications. Stress ulcer bleeding is a serious complication after acute ischemic stroke, with a prevalence of 1%-5%, and a previously proven incidence of stress ulcer bleeding after ischemic stroke. Stress ulcer bleeding after ischemic stroke has been shown to be closely associated with unfavorable outcomes, such as mortality. Current national and international guidelines or consensus on the prevention of stress ulcers after acute ischemic stroke do not advocate the routine use of histamine receptor antagonists or proton pump inhibitors for the prevention of stress ulcers, but rather should be considered in the context of the patient's risk factors for stress ulcers and discontinued after the patient initiates enteral nutrition. However, there is no evidence-based medical evidence to support the risk-benefit relationship of stress ulcer drug prophylaxis in patients with mechanical thrombectomy for acute anterior circulation large vessel occlusion.