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ERβ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells

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收录情况： ◇ SCIE

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机构： [1] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Breast Surg,Breast Canc Inst,Shanghai Canc C, Shanghai 200433, Peoples R China [2] Kanazawa Univ, Canc Res Inst, Div Mol Bioregulat, Kanazawa, Ishikawa 920, Japan [3] Chongqing Med Univ, Affiliated Hosp 2, Dept Gen Surg, Chongqing, Peoples R China

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Metastasis represents the major remaining cause of mortality in human breast cancer. Interleukin-8 (IL-8), a proinflammatory chemokine, plays an important role during tumor angiogenesis and metastasis. In this study, we found that IL-8 and ERbeta (ER beta) showed positive association. Overexpression of ER beta or PEA 3 could upregulate IL-8 promoter activity, mRNA and secretion; silencing of ER beta or PEA 3 decreased IL-8 mRNA and secretion. ER beta and PEA 3 increased IL-8 expression through binding to the IL-8 promoter and increased cell invasion. HER2 could increase ER beta and PEA 3 expression and their binding to the IL-8 promoter. We conclude that ER beta and PEA 3 play important roles in tumor invasion by regulating IL-8 expression, and HER2 maybe the upstream of ER beta and PEA3-IL-8 pathway.

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出版当年[2010]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

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出版当年[2009]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 4.4 最新[2023版] 4.4 最新五年平均 2.711 出版当年[2009版] 3.049 出版当年五年平均 2.761 出版前一年[2008版] 2.907 出版后一年[2010版]

第一作者：

第一作者机构： [1] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Breast Surg,Breast Canc Inst,Shanghai Canc C, Shanghai 200433, Peoples R China

通讯作者：

通讯机构： [1] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Breast Surg,Breast Canc Inst,Shanghai Canc C, Shanghai 200433, Peoples R China [*1]Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Breast Surg,Breast Canc Inst,Shanghai Canc C, Shanghai 200433, Peoples R China

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