机构:[1] Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2] Guangzhou Univ Tradit Chinese Med, Postdoctoral Res Stn, Guangzhou 510006, Guangdong, Peoples R China
This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson's disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinson's disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.
第一作者机构:[1] Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2] Guangzhou Univ Tradit Chinese Med, Postdoctoral Res Stn, Guangzhou 510006, Guangdong, Peoples R China[*1]Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China
通讯作者:
通讯机构:[1] Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[*1]Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China
推荐引用方式(GB/T 7714):
Luo Enli.Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction[J].NEURAL REGENERATION RESEARCH.2011,6(12):914-918.