机构：[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China[2] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China[3] Univ N Carolina, Ctr Res Comp, Chapel Hill, NC 27599 USA[4] Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China
Base-mediated decomposition of amide-substituted furfuryl tosylhydrazones afforded practical access to novel multifunctionalized enynyl-ketoamides. In addition, furfuryl tosylhydrazones with stable furan rings underwent an interesting tosyl-group migration to form sulfones, which have potential synthetic applications. Some of the obtained enynyl-ketoamides demonstrated good cytotoxicities against human tumor cell lines.
基金：
National Natural Science
Foundation of China (21272078, 81202398, and 21336002),
Fundamental Research Funds for the Central Universities
(2014ZG0027), Natural Science Foundation of Guangdong
Province, China (10351064101000000), and Program for New
Century Excellent Talents in Universities (NCET-12-0189).
第一作者机构：[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China
通讯作者：
通讯机构：[*1]Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China[4] Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Ji Fanghua,Peng Hui,Zhang Xiaoting,等.Base-Mediated Decomposition of Amide-Substituted Furfuryl Tosylhydrazones: Synthesis and Cytotoxic Activities of Enynyl-Ketoamides[J].JOURNAL OF ORGANIC CHEMISTRY.2015,80(4):2092-2102.
化学