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Flavonoid glycosides from Rubus chingii Hu fruits display anti-inflammatory activity through suppressing MAPKs activation in macrophages

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机构: [1] S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China [2] Guangzhou Univ Chinese Med, Inst Clin Med 2, Guangzhou 510120, Guangdong, Peoples R China
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摘要:
Rubus chingii Hu has been used as a functional food for a long time. This work was aimed to identify the anti-inflammatory ingredients from R. chingii by an activity-guided isolation. The ethanol extracts of R. chingii were partitioned into petroleum ether, ethyl acetate, butanol and water fractions, and the ethyl acetate fraction exhibited excellent anti-inflammatory activity. Five flavonoid glycosides were isolated from the ethyl acetate fraction based on anti-inflammatory assay-guided purification, which were identified as quercitrin, hyperoside, tiliroside, astragalin and kaempferol 3-rutinoside. The inhibitory effects of extract fractions and compounds on NO production in LPS-stimulated macrophage RAW 264.7 cells were evaluated. The five flavonoid glycosides displayed different degrees of anti-inflammatory activity, among which tiliroside showed stronger activity than others. Further analysis showed that the anti-inflammatory activity of tiliroside might be exerted through inhibiting the activation of ERK and JNK to decrease NO and pro-inflammatory cytokines (TNF-alpha, iNOS and IL-6) production. (C) 2015 Elsevier Ltd. All rights reserved.

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中科院(CAS)分区:
出版当年[2014]版:
大类 | 2 区 工程技术
小类 | 2 区 食品科技
最新[2025]版:
大类 | 2 区 农林科学
小类 | 3 区 食品科技 4 区 营养学
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出版当年[2013]版:
Q1 FOOD SCIENCE & TECHNOLOGY
最新[2023]版:
Q2 FOOD SCIENCE & TECHNOLOGY Q2 NUTRITION & DIETETICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

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第一作者机构: [1] S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China
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通讯机构: [1] S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China [*1]S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China
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